Grand Challenges at the Interface of Engineering and Medicine
Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in b...
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2024-01-01
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| author | Shankar Subramaniam Metin Akay Mark A. Anastasio Vasudev Bailey David Boas Paolo Bonato Ashutosh Chilkoti Jennifer R. Cochran Vicki Colvin Tejal A. Desai James S. Duncan Frederick H. Epstein Stephanie Fraley Cecilia Giachelli K. Jane Grande-Allen Jordan Green X. Edward Guo Isaac B. Hilton Jay D. Humphrey Chris R Johnson George Karniadakis Michael R. King Robert F. Kirsch Sanjay Kumar Cato T. Laurencin Song Li Richard L. Lieber Nigel Lovell Prashant Mali Susan S. Margulies David F. Meaney Brenda Ogle Bernhard Palsson Nicholas A. Peppas Eric J. Perreault Rick Rabbitt Lori A. Setton Lonnie D. Shea Sanjeev G. Shroff Kirk Shung Andreas S. Tolias Marjolein C.H. van der Meulen Shyni Varghese Gordana Vunjak-Novakovic John A. White Raimond Winslow Jianyi Zhang Kun Zhang Charles Zukoski Michael I. Miller |
| author_facet | Shankar Subramaniam Metin Akay Mark A. Anastasio Vasudev Bailey David Boas Paolo Bonato Ashutosh Chilkoti Jennifer R. Cochran Vicki Colvin Tejal A. Desai James S. Duncan Frederick H. Epstein Stephanie Fraley Cecilia Giachelli K. Jane Grande-Allen Jordan Green X. Edward Guo Isaac B. Hilton Jay D. Humphrey Chris R Johnson George Karniadakis Michael R. King Robert F. Kirsch Sanjay Kumar Cato T. Laurencin Song Li Richard L. Lieber Nigel Lovell Prashant Mali Susan S. Margulies David F. Meaney Brenda Ogle Bernhard Palsson Nicholas A. Peppas Eric J. Perreault Rick Rabbitt Lori A. Setton Lonnie D. Shea Sanjeev G. Shroff Kirk Shung Andreas S. Tolias Marjolein C.H. van der Meulen Shyni Varghese Gordana Vunjak-Novakovic John A. White Raimond Winslow Jianyi Zhang Kun Zhang Charles Zukoski Michael I. Miller |
| author_sort | Shankar Subramaniam |
| collection | DOAJ |
| description | Over the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in both non-invasive and invasive modes. The multiple scales at which human physiology can be interrogated provide a profound perspective on health and disease. We are at the nexus of creating “avatars” (herein defined as an extension of “digital twins”) of human patho/physiology to serve as paradigms for interrogation and potential intervention. Motivated by the emergence of these new capabilities, the IEEE Engineering in Medicine and Biology Society, the Departments of Biomedical Engineering at Johns Hopkins University and Bioengineering at University of California at San Diego sponsored an interdisciplinary workshop to define the grand challenges that face biomedical engineering and the mechanisms to address these challenges. The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells. |
| format | Article |
| id | doaj-art-99aa19c8944b4368939a87375caa3abd |
| institution | Kabale University |
| issn | 2644-1276 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Open Journal of Engineering in Medicine and Biology |
| spelling | doaj-art-99aa19c8944b4368939a87375caa3abd2025-01-30T00:03:40ZengIEEEIEEE Open Journal of Engineering in Medicine and Biology2644-12762024-01-01511310.1109/OJEMB.2024.335171710443312Grand Challenges at the Interface of Engineering and MedicineShankar Subramaniam0https://orcid.org/0000-0002-8059-4659Metin Akay1https://orcid.org/0000-0002-2988-4669Mark A. Anastasio2https://orcid.org/0000-0002-3192-4172Vasudev Bailey3https://orcid.org/0009-0006-4070-3212David Boas4https://orcid.org/0000-0002-6709-7711Paolo Bonato5https://orcid.org/0000-0002-1818-1714Ashutosh Chilkoti6https://orcid.org/0000-0002-1569-2228Jennifer R. Cochran7https://orcid.org/0000-0002-6532-9873Vicki Colvin8https://orcid.org/0000-0002-8526-515XTejal A. Desai9https://orcid.org/0000-0003-3409-9208James S. Duncan10https://orcid.org/0000-0002-5167-9856Frederick H. Epstein11https://orcid.org/0000-0002-1954-1988Stephanie Fraley12https://orcid.org/0000-0003-1548-4442Cecilia Giachelli13https://orcid.org/0000-0002-6387-5993K. Jane Grande-Allen14https://orcid.org/0000-0003-1533-3767Jordan Green15https://orcid.org/0000-0003-4176-3808X. Edward Guo16https://orcid.org/0000-0003-0804-7279Isaac B. Hilton17https://orcid.org/0000-0002-3064-8532Jay D. Humphrey18https://orcid.org/0000-0003-1011-2025Chris R Johnson19https://orcid.org/0000-0001-5673-5338George Karniadakis20https://orcid.org/0000-0002-9713-7120Michael R. King21https://orcid.org/0000-0002-0223-7808Robert F. Kirsch22https://orcid.org/0000-0003-2564-1800Sanjay Kumar23https://orcid.org/0000-0002-9996-4883Cato T. Laurencin24https://orcid.org/0000-0001-6765-3047Song Li25https://orcid.org/0000-0002-4760-8828Richard L. Lieber26https://orcid.org/0000-0002-7203-4520Nigel Lovell27https://orcid.org/0000-0003-1637-1079Prashant Mali28https://orcid.org/0000-0002-3383-1287Susan S. Margulies29https://orcid.org/0000-0002-3615-7902David F. Meaney30https://orcid.org/0000-0002-0954-4122Brenda Ogle31https://orcid.org/0000-0001-7613-7490Bernhard Palsson32https://orcid.org/0000-0003-2357-6785Nicholas A. Peppas33https://orcid.org/0000-0003-0894-5626Eric J. Perreault34https://orcid.org/0000-0002-9860-6427Rick Rabbitt35https://orcid.org/0000-0002-2959-7248Lori A. Setton36https://orcid.org/0000-0001-5992-4206Lonnie D. Shea37https://orcid.org/0000-0002-9296-9673Sanjeev G. Shroff38https://orcid.org/0000-0003-1868-3826Kirk Shung39https://orcid.org/0000-0001-8475-3277Andreas S. Tolias40https://orcid.org/0000-0002-4305-6376Marjolein C.H. van der Meulen41https://orcid.org/0000-0001-6637-9808Shyni Varghese42https://orcid.org/0000-0002-0004-7947Gordana Vunjak-Novakovic43https://orcid.org/0000-0002-9382-1574John A. White44https://orcid.org/0000-0003-1073-2638Raimond Winslow45https://orcid.org/0000-0003-1719-1651Jianyi Zhang46https://orcid.org/0000-0002-3955-6554Kun Zhang47https://orcid.org/0000-0002-7596-5224Charles Zukoski48https://orcid.org/0009-0003-4885-7505Michael I. Miller49https://orcid.org/0000-0003-4689-3855Joan and Irwin Jacobs Endowed Chair in Bioengineering and Systems Biology, Distinguished Professor of Bioengineering, Computer Science & Engineering, Cellular & Molecular Medicine, and Nanoengineering, University of California San Diego, La Jolla, CA, USADepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USADepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USADepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USAProfessor of Biomedical Engineering and Director of Neurophotonics Center, Boston University College of Engineering, Boston, MA, USADepartment of Physical Medicine and Rehabilitation, Harvard Medical School, Spaulding Rehabilitation Hospital, Charlestown, MA, USAAlan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering, Duke University, Durham, NC, USASenior Associate Vice Provost for Research and Addie and Al Macovski Professor of Bioengineering, Shriram Center, Stanford University Schools of Medicine and Engineering, Stanford, CA, USAVernon K Krieble Professor of Chemistry and Professor of Engineering, Brown University, Providence, RI, USASorensen Family Dean of Engineering and Professor of Engineering, Brown University, Providence, RI, USAEbenezer K. Hunt Professor and Chair of Biomedical Engineering, Professor of Radiology & Biomedical Imaging, Yale University, New Haven, CT, USAMac Wade Professor of Biomedical Engineering and Professor of Radiology and Medical Imaging, Associate Dean for Research, School of Engineering and Applied Science, Charlottesville, VA, USAAssociate Professor of Bioengineering, University of California San Diego, La Jolla, CA, USASteven R. and Connie R. Rogel Endowed Professor for Cardiovascular Innovation in Bioengineering, Associate Vice Provost for Research, Seattle, WA, USAIsabel C. Cameron Professor of Bioengineering, Department of Bioengineering, Rice University, Houston, TX, USABiomedical Engineering and Vice Chair for Research and Translation, Department of Biomedical Engineering, Baltimore, MD, USAProfessor of Biomedical Engineering and Department Chair, New York, NY, USAAssistant Professor of Bioengineering and BioSciences, Rice University, Houston, TX, USAJohn C. Malone Professor of Biomedical Engineering, Yale University, New Haven, CT, USADistinguished Professor of Computer Science, Research Professor of Bioengineering, University of Utah, Salt Lake City, UT, USAThe Charles Pitts Robinson and John Palmer Barstow Professor of Applied Mathematics and Engineering, Brown University, Providence, RI, USAJ. Lawrence Wilson Professor of Engineering, Chair, Department of Biomedical Engineering, Professor of Biomedical Engineering, Professor of Radiology and Radiological Sciences, 5824 Stevenson Center, Nashville, TN, USAAllen H. and Constance T. Ford Professor and Chair of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USACalifornia Institute for Quantitative Biosciences, UC Berkeley, Berkeley, CA, USAUniversity Professor and Albert and Wilda Van Dusen Distinguished Endowed Professor of Orthopaedic Surgery, CEO, The Cato T. Laurencin Institute for Regenerative Engineering, Uconn, Farmington, CT, USADepartment of Bioengineering, UCLA Samueli School of Engineering, Los Angeles, CA, USAChief Scientific Officer and Senior Vice President, Shirley Ryan Ability Lab, Professor of Physiology and Biomedical Engineering, Northwestern University, Evanston, IL, USAUSAGraduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW, AustraliaProfessor of Bioengineering, University of California San Diego, La Jolla, CA, USAWallace H. Coulter Chair and Professor of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USAProfessor and Senior Associate Dean, Penn Engineering, Philadelphia, PA, USADepartment of Biomedical Engineering, Professor, Department of Pediatrics, Director, Stem Cell Institute, University of Minnesota-Twin Cities, Minneapolis, MN, USAY.C. Fung Endowed Professor in Bioengineering, Professor of Pediatrics, University of California San Diego, La Jolla, CA, USACockrell Family Regents Chair in Engineering, Director, Institute of Biomaterials, Drug Delivery and Regenerative Medicine, Professor, McKetta Department of Chemical Engineering, Department of Biomedical Engineering, Department of Pediatrics, Department of Surgery and Perioperative Care, Dell Medical School, and Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, USAVice President for Research, Professor of Biomedical Engineering, Professor of Physical Medicine and Rehabilitation, Northwestern University, Evanston, IL, USAProfessor of Biomedical Engineering, Neuroscience Program, Sal Lake City, UT, USADepartment Chair, Lucy & Stanley Lopata Distinguished Professor of Biomedical Engineering, Washington University in St. Louis, McKelvey School of Engineering, St. Louis, MO, USABiomedical Engineering, University of Michigan, Ann Arbor, MI, USADistinguished Professor of and Gerald E. McGinnis Chair in Bioengineering, Professor of Medicine, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, PA, USAProfessor Emeritus of Biomedical Engineering, Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USADepartment of Neuroscience, Baylor College of Medicine, Houston, TX, USAMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY, USAProfessor of Biomedical Engineering, Mechanical Engineering & Materials Science and Orthopaedics, Duke University, Durham, NC, USAUniversity and Mikati Foundation Professor of Biomedical Engineering and Medical Sciences, Columbia University, New York, NY, USAProfessor and Chair Department of Biomedical Engineering, Boston University, Boston, MA, USADirector of Life Science and Medical Research; Professor of Bioengineering, Northeastern University, Portland, ME, USADepartment of Biomedical Engineering, T. Michael and Gillian Goodrich Endowed Chair of Engineering Leadership, Professor of Medicine, of Engineering, School of Medicine, School of Engineering, UAB | The University of Alabama at Birmingham, U.K.Chair/Professor of Bioengineering, University of California San Diego, La Jolla, CA, USAShelly and Ofer Nemirovsky Provost's Chair and Professor of Chemical Engineering and Materials Science and Biomedical Engineering, Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USABessie Darling Massey Professor and Director, Department of Biomedical Engineering, Co-Director, Kavli Neuroscience Discovery Institute, Johns Hopkins University School of Medicine and Whiting School of Engineering, Baltimore, MD, USAOver the past two decades Biomedical Engineering has emerged as a major discipline that bridges societal needs of human health care with the development of novel technologies. Every medical institution is now equipped at varying degrees of sophistication with the ability to monitor human health in both non-invasive and invasive modes. The multiple scales at which human physiology can be interrogated provide a profound perspective on health and disease. We are at the nexus of creating “avatars” (herein defined as an extension of “digital twins”) of human patho/physiology to serve as paradigms for interrogation and potential intervention. Motivated by the emergence of these new capabilities, the IEEE Engineering in Medicine and Biology Society, the Departments of Biomedical Engineering at Johns Hopkins University and Bioengineering at University of California at San Diego sponsored an interdisciplinary workshop to define the grand challenges that face biomedical engineering and the mechanisms to address these challenges. The Workshop identified five grand challenges with cross-cutting themes and provided a roadmap for new technologies, identified new training needs, and defined the types of interdisciplinary teams needed for addressing these challenges. The themes presented in this paper include: 1) accumedicine through creation of avatars of cells, tissues, organs and whole human; 2) development of smart and responsive devices for human function augmentation; 3) exocortical technologies to understand brain function and treat neuropathologies; 4) the development of approaches to harness the human immune system for health and wellness; and 5) new strategies to engineer genomes and cells.https://ieeexplore.ieee.org/document/10443312/Genome-engineeringhuman function augmentationimmuno-engineeringprecision medicinedigital twinsneuroimaging |
| spellingShingle | Shankar Subramaniam Metin Akay Mark A. Anastasio Vasudev Bailey David Boas Paolo Bonato Ashutosh Chilkoti Jennifer R. Cochran Vicki Colvin Tejal A. Desai James S. Duncan Frederick H. Epstein Stephanie Fraley Cecilia Giachelli K. Jane Grande-Allen Jordan Green X. Edward Guo Isaac B. Hilton Jay D. Humphrey Chris R Johnson George Karniadakis Michael R. King Robert F. Kirsch Sanjay Kumar Cato T. Laurencin Song Li Richard L. Lieber Nigel Lovell Prashant Mali Susan S. Margulies David F. Meaney Brenda Ogle Bernhard Palsson Nicholas A. Peppas Eric J. Perreault Rick Rabbitt Lori A. Setton Lonnie D. Shea Sanjeev G. Shroff Kirk Shung Andreas S. Tolias Marjolein C.H. van der Meulen Shyni Varghese Gordana Vunjak-Novakovic John A. White Raimond Winslow Jianyi Zhang Kun Zhang Charles Zukoski Michael I. Miller Grand Challenges at the Interface of Engineering and Medicine IEEE Open Journal of Engineering in Medicine and Biology Genome-engineering human function augmentation immuno-engineering precision medicine digital twins neuroimaging |
| title | Grand Challenges at the Interface of Engineering and Medicine |
| title_full | Grand Challenges at the Interface of Engineering and Medicine |
| title_fullStr | Grand Challenges at the Interface of Engineering and Medicine |
| title_full_unstemmed | Grand Challenges at the Interface of Engineering and Medicine |
| title_short | Grand Challenges at the Interface of Engineering and Medicine |
| title_sort | grand challenges at the interface of engineering and medicine |
| topic | Genome-engineering human function augmentation immuno-engineering precision medicine digital twins neuroimaging |
| url | https://ieeexplore.ieee.org/document/10443312/ |
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