Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization
The aim of this project is to fabricate fiber mats and hydrogel materials that constitute the two main components of a wound dressing material. The contributions of boric acid (BA) and zinc oxide (ZnO) to the physical and mechanical properties of polycaprolactone (PCL) is investigated. These materia...
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2025-01-01
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| author | Barkin Aydin Nihat Arol Nimet Burak Aybala Usta Muhammet Ceylan |
| author_facet | Barkin Aydin Nihat Arol Nimet Burak Aybala Usta Muhammet Ceylan |
| author_sort | Barkin Aydin |
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| description | The aim of this project is to fabricate fiber mats and hydrogel materials that constitute the two main components of a wound dressing material. The contributions of boric acid (BA) and zinc oxide (ZnO) to the physical and mechanical properties of polycaprolactone (PCL) is investigated. These materials are chosen for their antimicrobial and antifungal effects. Additionally, since chitosan forms brittle hydrogels, it is reinforced with polyvinyl alcohol (PVA) to improve ductility and water uptake properties. For these purposes, PCL, BA, ZnO, PVA, and chitosan are used in different ratios to fabricate nanofiber mats and hydrogels. Mechanical, physical, and chemical characteristics are examined. The highest elastic modulus and tensile strength are obtained from samples with 6% BA and 10% ZnO concentrations. ZnO-decorated fibers exhibit a higher elastic modulus than those with BA, though BA-containing fibers exhibit greater elongation before breakage. All fibers exhibit hydrophobic properties, which help to prevent biofilm formation. In compression tests, CS12 demonstrates the highest strength. Increasing the PVA content enhances ductility, while a higher concentration of chitosan results in a denser structure. This outcome is confirmed by FTIR and swelling tests. These findings highlight the optimal combinations of nanofibrous mats and hydrogels, offering guidance for future wound dressing designs that balance mechanical strength, water absorption, and antimicrobial properties. By stacking these nanofibrous mats and hydrogels in different orders, it is expected to achieve a wound care material that is suitable for various applications. The authors encourage experimentation with different configurations of these nanofiber and hydrogel stackings to observe their mechanical behavior under real-life conditions in future studies. |
| format | Article |
| id | doaj-art-99a202642b9a489dbca71dea55c86e31 |
| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-99a202642b9a489dbca71dea55c86e312025-01-24T13:33:52ZengMDPI AGGels2310-28612025-01-011113910.3390/gels11010039Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical CharacterizationBarkin Aydin0Nihat Arol1Nimet Burak2Aybala Usta3Muhammet Ceylan4Department of Mechanical Engineering, Engineering Faculty, Marmara University, 34854 Istanbul, TürkiyeDepartment of Mechanical Engineering, Engineering Faculty, Marmara University, 34854 Istanbul, TürkiyeDepartment of Mechanical Engineering, Engineering Faculty, Marmara University, 34854 Istanbul, TürkiyeDepartment of Mechanical Engineering, Engineering Faculty, Marmara University, 34854 Istanbul, TürkiyeDepartment of Mechatronics Engineering, Engineering Faculty, Istanbul Ticaret University, 34854 Istanbul, TürkiyeThe aim of this project is to fabricate fiber mats and hydrogel materials that constitute the two main components of a wound dressing material. The contributions of boric acid (BA) and zinc oxide (ZnO) to the physical and mechanical properties of polycaprolactone (PCL) is investigated. These materials are chosen for their antimicrobial and antifungal effects. Additionally, since chitosan forms brittle hydrogels, it is reinforced with polyvinyl alcohol (PVA) to improve ductility and water uptake properties. For these purposes, PCL, BA, ZnO, PVA, and chitosan are used in different ratios to fabricate nanofiber mats and hydrogels. Mechanical, physical, and chemical characteristics are examined. The highest elastic modulus and tensile strength are obtained from samples with 6% BA and 10% ZnO concentrations. ZnO-decorated fibers exhibit a higher elastic modulus than those with BA, though BA-containing fibers exhibit greater elongation before breakage. All fibers exhibit hydrophobic properties, which help to prevent biofilm formation. In compression tests, CS12 demonstrates the highest strength. Increasing the PVA content enhances ductility, while a higher concentration of chitosan results in a denser structure. This outcome is confirmed by FTIR and swelling tests. These findings highlight the optimal combinations of nanofibrous mats and hydrogels, offering guidance for future wound dressing designs that balance mechanical strength, water absorption, and antimicrobial properties. By stacking these nanofibrous mats and hydrogels in different orders, it is expected to achieve a wound care material that is suitable for various applications. The authors encourage experimentation with different configurations of these nanofiber and hydrogel stackings to observe their mechanical behavior under real-life conditions in future studies.https://www.mdpi.com/2310-2861/11/1/39PCLelectrospinningboric acidzinc oxidehydrogelchitosan |
| spellingShingle | Barkin Aydin Nihat Arol Nimet Burak Aybala Usta Muhammet Ceylan Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization Gels PCL electrospinning boric acid zinc oxide hydrogel chitosan |
| title | Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization |
| title_full | Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization |
| title_fullStr | Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization |
| title_full_unstemmed | Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization |
| title_short | Investigation of Chitosan-Based Hydrogels and Polycaprolactone-Based Electrospun Fibers as Wound Dressing Materials Based on Mechanical, Physical, and Chemical Characterization |
| title_sort | investigation of chitosan based hydrogels and polycaprolactone based electrospun fibers as wound dressing materials based on mechanical physical and chemical characterization |
| topic | PCL electrospinning boric acid zinc oxide hydrogel chitosan |
| url | https://www.mdpi.com/2310-2861/11/1/39 |
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