Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers
<p>We investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed offic...
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| Format: | Article |
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| Language: | English |
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Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/24827 |
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| description | <p>We investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed office workers) underwent IS induction. Samples were processed by conventional methods within 2 hours. The proportion of particles with diameters of 0–2 <mml:math alttext="$mu$"> <mml:mi>μ</mml:mi> </mml:math> in IS samples was significantly higher in nonexposed than exposed workers and in smoker compared to nonsmoker workers. MMP-9 and TIMP-1 levels were similar for both groups. A linear regression model for MMP-9 based on exposure, smoking habits, and proportion of particles <mml:math alttext="$<5$"> <mml:mrow> <mml:mo><</mml:mo><mml:mn>5</mml:mn> </mml:mrow> </mml:math> <mml:math alttext="$mu$"> <mml:mi>μ</mml:mi> </mml:math> revealed a positive correlation between each of the explanatory variables and MMP-9 values. MMP-9 may serve as a marker for pulmonary injury.</p> |
| format | Article |
| id | doaj-art-998599a98f934536abafc50c3b8581c2 |
| institution | Kabale University |
| issn | 0962-9351 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-998599a98f934536abafc50c3b8581c22025-02-03T01:02:34ZengWileyMediators of Inflammation0962-93512006-01-012006Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers<p>We investigated whether metalloproteinase-9 (MMP-9) values in induced sputum (IS) and pulmonary function tests can serve as a marker of damage and intensity of exposure to hazardous dust. Thirty-nine factory employees (28 workers exposed to metal particles and 11 supposedly nonexposed office workers) underwent IS induction. Samples were processed by conventional methods within 2 hours. The proportion of particles with diameters of 0–2 <mml:math alttext="$mu$"> <mml:mi>μ</mml:mi> </mml:math> in IS samples was significantly higher in nonexposed than exposed workers and in smoker compared to nonsmoker workers. MMP-9 and TIMP-1 levels were similar for both groups. A linear regression model for MMP-9 based on exposure, smoking habits, and proportion of particles <mml:math alttext="$<5$"> <mml:mrow> <mml:mo><</mml:mo><mml:mn>5</mml:mn> </mml:mrow> </mml:math> <mml:math alttext="$mu$"> <mml:mi>μ</mml:mi> </mml:math> revealed a positive correlation between each of the explanatory variables and MMP-9 values. MMP-9 may serve as a marker for pulmonary injury.</p>http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/24827 |
| spellingShingle | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers Mediators of Inflammation |
| title | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_full | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_fullStr | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_full_unstemmed | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_short | Unexpected Smoking-Linked High MMP-9 in Induced Sputum of Hazardous Dust-Exposed Workers |
| title_sort | unexpected smoking linked high mmp 9 in induced sputum of hazardous dust exposed workers |
| url | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/24827 |