Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes

Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes

Abstract Background Skin barrier dysfunction and immune activation are hallmarks of inflammatory skin diseases such as rosacea and psoriasis, suggesting shared pathogenic mechanisms. While barrier disruption may trigger or exacerbate skin inflammation, the precise underlying mechanisms remain unclea...

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Bibliographic Details
Main Authors: Mengting Chen, Yaling Wang, Mei Wang, San Xu, Zixin Tan, Yisheng Cai, Xin Xiao, Ben Wang, Zhili Deng, Ji Li
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biomedical Science
Subjects:
Keratin 6
Rosacea
Psoriasis
Inflammation
JAK1-STAT3
Online Access:https://doi.org/10.1186/s12929-025-01143-9
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