Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity
Curcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic proce...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2015/630246 |
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| author | Prabhakar Singh Syed Ibrahim Rizvi |
| author_facet | Prabhakar Singh Syed Ibrahim Rizvi |
| author_sort | Prabhakar Singh |
| collection | DOAJ |
| description | Curcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic process, and antiangiogenic property. We explored the effects of curcumin in vitro (10−5 M to 10−8 M) and in vivo (340 and 170 mg/kg b.w., oral) on Na+/K+ ATPase (NKA), Na+/H+ exchanger (NHE) activity, and membrane lipid hydroperoxides (ROOH) in control and experimental oxidative stress erythrocytes of Wistar rats. As a result, we found that curcumin potently modulated the membrane transporters activity with protecting membrane lipids against hydro-peroxidation in control as well as oxidatively challenged erythrocytes evidenced by stimulation of NKA, downregulation of NHE, and reduction of ROOH in the membrane. The observed results corroborate membrane transporters activity with susceptibility of erythrocyte membrane towards oxidative damage. Results explain the protective mechanism of curcumin against oxidative stress mediated impairment in ions-transporters activity and health beneficial effects. |
| format | Article |
| id | doaj-art-996f520446f94d2baeadd8bdb49ea97a |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-996f520446f94d2baeadd8bdb49ea97a2025-02-03T05:44:43ZengWileyInternational Journal of Cell Biology1687-88761687-88842015-01-01201510.1155/2015/630246630246Modulation Effects of Curcumin on Erythrocyte Ion-Transporter ActivityPrabhakar Singh0Syed Ibrahim Rizvi1Department of Biochemistry, University of Allahabad, Allahabad 211002, IndiaDepartment of Biochemistry, University of Allahabad, Allahabad 211002, IndiaCurcumin ((1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione), the yellow biphenolic pigment isolated from turmeric (Curcuma longa), has various medicinal benefits through antioxidation, anti-inflammation, cardiovascular protection, immunomodulation, enhancing of the apoptotic process, and antiangiogenic property. We explored the effects of curcumin in vitro (10−5 M to 10−8 M) and in vivo (340 and 170 mg/kg b.w., oral) on Na+/K+ ATPase (NKA), Na+/H+ exchanger (NHE) activity, and membrane lipid hydroperoxides (ROOH) in control and experimental oxidative stress erythrocytes of Wistar rats. As a result, we found that curcumin potently modulated the membrane transporters activity with protecting membrane lipids against hydro-peroxidation in control as well as oxidatively challenged erythrocytes evidenced by stimulation of NKA, downregulation of NHE, and reduction of ROOH in the membrane. The observed results corroborate membrane transporters activity with susceptibility of erythrocyte membrane towards oxidative damage. Results explain the protective mechanism of curcumin against oxidative stress mediated impairment in ions-transporters activity and health beneficial effects.http://dx.doi.org/10.1155/2015/630246 |
| spellingShingle | Prabhakar Singh Syed Ibrahim Rizvi Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity International Journal of Cell Biology |
| title | Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity |
| title_full | Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity |
| title_fullStr | Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity |
| title_full_unstemmed | Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity |
| title_short | Modulation Effects of Curcumin on Erythrocyte Ion-Transporter Activity |
| title_sort | modulation effects of curcumin on erythrocyte ion transporter activity |
| url | http://dx.doi.org/10.1155/2015/630246 |
| work_keys_str_mv | AT prabhakarsingh modulationeffectsofcurcuminonerythrocyteiontransporteractivity AT syedibrahimrizvi modulationeffectsofcurcuminonerythrocyteiontransporteractivity |