Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis
Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including the pancreas and salivary glands. Immunological abnormalities...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-02-01
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| Series: | Immunological Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/25785826.2025.2460910 |
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| author | Nanako Kikuchi Sae Hatanaka Terufumi Kubo Ryuta Kamekura Masatoshi Kanda Takuya Kakuki Takashi Sasaya Kengo Mita Hiroki Kobayashi Hajime Ikai Kenta Sasaki Naoki Shijubou Kenji Murata Takayuki Kanaseki Tomohide Tsukahara Yoshihiko Hirohashi Tadashi Hasegawa Akihiro Miyazaki Hiroki Takahashi Ken-ichi Takano Toshihiko Torigoe |
| author_facet | Nanako Kikuchi Sae Hatanaka Terufumi Kubo Ryuta Kamekura Masatoshi Kanda Takuya Kakuki Takashi Sasaya Kengo Mita Hiroki Kobayashi Hajime Ikai Kenta Sasaki Naoki Shijubou Kenji Murata Takayuki Kanaseki Tomohide Tsukahara Yoshihiko Hirohashi Tadashi Hasegawa Akihiro Miyazaki Hiroki Takahashi Ken-ichi Takano Toshihiko Torigoe |
| author_sort | Nanako Kikuchi |
| collection | DOAJ |
| description | Immunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including the pancreas and salivary glands. Immunological abnormalities are suspected to play a role in its pathogenesis, and there is an epidemiological link to allergic conditions and type 2 inflammation. This study focused on the expression of thymus and activation-regulated chemokine (TARC)/CCL17, which is involved in the migration of T helper 2 and/or regulatory T cells, in salivary gland tissues of patients with IgG4-RD. We analyzed 60 salivary gland biopsy samples obtained from patients at Sapporo Medical University Hospital between 2015 and 2020. Immunohistochemical analysis revealed TARC/CCL17 positivity in 87.2% of histologically confirmed IgG4-RD cases and negativity in 84.6% of histologically unconfirmed but clinically suspected IgG4-RD cases. There was a significant correlation between histologically confirmed IgG4-RD and TARC/CCL17 expression, suggesting its potential diagnostic utility and possible involvement in the pathogenesis of IgG4-RD. |
| format | Article |
| id | doaj-art-99664884a7994057bd3dc68d0ae1fd39 |
| institution | Kabale University |
| issn | 2578-5826 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj-art-99664884a7994057bd3dc68d0ae1fd392025-02-04T13:48:58ZengTaylor & Francis GroupImmunological Medicine2578-58262025-02-011710.1080/25785826.2025.2460910Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesisNanako Kikuchi0Sae Hatanaka1Terufumi Kubo2Ryuta Kamekura3Masatoshi Kanda4Takuya Kakuki5Takashi Sasaya6Kengo Mita7Hiroki Kobayashi8Hajime Ikai9Kenta Sasaki10Naoki Shijubou11Kenji Murata12Takayuki Kanaseki13Tomohide Tsukahara14Yoshihiko Hirohashi15Tadashi Hasegawa16Akihiro Miyazaki17Hiroki Takahashi18Ken-ichi Takano19Toshihiko Torigoe20Department of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Oral Surgery, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Surgical Pathology, Sapporo Medical University Hospital, Sapporo, JapanDepartment of Oral Surgery, Sapporo Medical University, School of Medicine, Sapporo, JapanDepartment of Rheumatology and Clinical Immunology, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Otolaryngology-Head and Neck Surgery, Sapporo Medical University School of Medicine, Sapporo, JapanDepartment of Pathology, Sapporo Medical University, School of Medicine, Sapporo, JapanImmunoglobulin G4-related disease (IgG4-RD) is a chronic inflammatory condition of unknown etiology characterized by lymphocytic infiltration, fibrosis, and infiltration of IgG4-positive plasma cells. It affects various organs, including the pancreas and salivary glands. Immunological abnormalities are suspected to play a role in its pathogenesis, and there is an epidemiological link to allergic conditions and type 2 inflammation. This study focused on the expression of thymus and activation-regulated chemokine (TARC)/CCL17, which is involved in the migration of T helper 2 and/or regulatory T cells, in salivary gland tissues of patients with IgG4-RD. We analyzed 60 salivary gland biopsy samples obtained from patients at Sapporo Medical University Hospital between 2015 and 2020. Immunohistochemical analysis revealed TARC/CCL17 positivity in 87.2% of histologically confirmed IgG4-RD cases and negativity in 84.6% of histologically unconfirmed but clinically suspected IgG4-RD cases. There was a significant correlation between histologically confirmed IgG4-RD and TARC/CCL17 expression, suggesting its potential diagnostic utility and possible involvement in the pathogenesis of IgG4-RD.https://www.tandfonline.com/doi/10.1080/25785826.2025.2460910IgG4-related diseasesalivary glandacinar cellthymus and activation-regulated chemokine (TARC)/CCL17 |
| spellingShingle | Nanako Kikuchi Sae Hatanaka Terufumi Kubo Ryuta Kamekura Masatoshi Kanda Takuya Kakuki Takashi Sasaya Kengo Mita Hiroki Kobayashi Hajime Ikai Kenta Sasaki Naoki Shijubou Kenji Murata Takayuki Kanaseki Tomohide Tsukahara Yoshihiko Hirohashi Tadashi Hasegawa Akihiro Miyazaki Hiroki Takahashi Ken-ichi Takano Toshihiko Torigoe Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis Immunological Medicine IgG4-related disease salivary gland acinar cell thymus and activation-regulated chemokine (TARC)/CCL17 |
| title | Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis |
| title_full | Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis |
| title_fullStr | Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis |
| title_full_unstemmed | Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis |
| title_short | Characteristic TARC/CCL17 expression in the salivary gland of IgG4-related disease: potential diagnostic utility and insights into pathogenesis |
| title_sort | characteristic tarc ccl17 expression in the salivary gland of igg4 related disease potential diagnostic utility and insights into pathogenesis |
| topic | IgG4-related disease salivary gland acinar cell thymus and activation-regulated chemokine (TARC)/CCL17 |
| url | https://www.tandfonline.com/doi/10.1080/25785826.2025.2460910 |
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