Impact of proteolysis processes on development and progressing of cardiac insufficiency of is chemic genesis depending on revascularisation
Investigation and comparative assessment of the activity of matrix metalloproteinases MMP-9 and MMP-2 in 187 patients with chronic ischemic heart disease and all forms of acute coronary syndrome mean age 62 ± 1,5 years in applying the standard basic therapy, thrombolytic and antithrombin therapy was...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dnipro State Medical University
2013-03-01
|
| Series: | Medičnì Perspektivi |
| Subjects: | |
| Online Access: | http://medpers.dsma.dp.ua/issues/2013/N1/37-43.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Investigation and comparative assessment of the activity of matrix metalloproteinases MMP-9 and MMP-2 in 187 patients with chronic ischemic heart disease and all forms of acute coronary syndrome mean age 62 ± 1,5 years in applying the standard basic therapy, thrombolytic and antithrombin therapy was carried out. It was established, that in patients with acute co¬ronary syndrome and chronic ischemic heart disease; diverse changes in activity of the processes of proteolysis are observed, the presence of heart failure leads to a comparative increase in the activity of MMP-2 and MMP-9 in patients with acute coronary syndrome, but a greater effect on these processes causes the time of the beginning of treatment and receiving thrombolytic therapy; significant increasing activity of both matrix metal-proteinases is associated with the long process of formation and progression of heart failure, with the development of severe chronic heart failure, a gradual decrease in activity of matrix metal-proteinases. |
|---|---|
| ISSN: | 2307-0404 2307-0404 |