Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study
ABSTRACT Background Emerging evidence suggests that the creatinine‐to‐body weight (Cre/BW) ratio is a predictor for incident diabetes in the Asian population. This study examined the association between Cre/BW ratio and incident diabetes, as well as the relationship between Cre/BW ratio and skeletal...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Journal of Diabetes |
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| Online Access: | https://doi.org/10.1111/1753-0407.70039 |
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| author | Noraidatulakma Abdullah Ying‐Xian Goh Aisyatul Najihah Khuzaimi Azwa Shawani Kamalul Arifin Nurul Ain Mhd Yusuf Nazihah Abd Jalal Norliza Ismail Nurul Faeizah Husin Mohd Arman Kamaruddin Rahman Jamal |
| author_facet | Noraidatulakma Abdullah Ying‐Xian Goh Aisyatul Najihah Khuzaimi Azwa Shawani Kamalul Arifin Nurul Ain Mhd Yusuf Nazihah Abd Jalal Norliza Ismail Nurul Faeizah Husin Mohd Arman Kamaruddin Rahman Jamal |
| author_sort | Noraidatulakma Abdullah |
| collection | DOAJ |
| description | ABSTRACT Background Emerging evidence suggests that the creatinine‐to‐body weight (Cre/BW) ratio is a predictor for incident diabetes in the Asian population. This study examined the association between Cre/BW ratio and incident diabetes, as well as the relationship between Cre/BW ratio and skeletal muscle and body fat mass in a multiethnic Malaysian cohort. Methods A total of 13 047 eligible participants were selected from 119 560 The Malaysian Cohort participants. Of these, 750 who developed diabetes were selected as cases, while 3750 controls were chosen randomly from healthy participants. This nested case–control study included 4500 eligible participants from The Malaysian Cohort, with a 1:5 case‐to‐control ratio. Participants were stratified into four groups based on Cre/BW ratio quartiles. The Cox proportional hazards model evaluated the effect of Cre/BW ratio on developing incident diabetes. The association between Cre/BW ratio and body composition was assessed using the Pearson correlation coefficient. Results Of the 13 047 eligible participants followed up over 5.3 years, 5.75% (n = 750) developed diabetes. Diabetes incidence decreased with increasing Cre/BW ratios. The Cre/BW ratio was inversely correlated with diabetes risk (HR: 0.403, 95% CI: 0.315–0.515, p < 0.001). Additionally, males and Indians had a higher risk of developing incident diabetes. A significant correlation was observed between Cre/BW ratio and body fat mass (p < 0.001). Conclusions This study reveals an inverse association between the Cre/BW ratio and incident diabetes. It also found a significant moderate correlation between the Cre/BW ratio and body fat mass. |
| format | Article |
| id | doaj-art-9956d276cae14735b103af6bbc681b15 |
| institution | Kabale University |
| issn | 1753-0393 1753-0407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj-art-9956d276cae14735b103af6bbc681b152025-01-28T04:44:58ZengWileyJournal of Diabetes1753-03931753-04072025-01-01171n/an/a10.1111/1753-0407.70039Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort StudyNoraidatulakma Abdullah0Ying‐Xian Goh1Aisyatul Najihah Khuzaimi2Azwa Shawani Kamalul Arifin3Nurul Ain Mhd Yusuf4Nazihah Abd Jalal5Norliza Ismail6Nurul Faeizah Husin7Mohd Arman Kamaruddin8Rahman Jamal9UKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaUKM Medical Molecular Biology Institute (UMBI) Universiti Kebangsaan Malaysia Kuala Lumpur MalaysiaABSTRACT Background Emerging evidence suggests that the creatinine‐to‐body weight (Cre/BW) ratio is a predictor for incident diabetes in the Asian population. This study examined the association between Cre/BW ratio and incident diabetes, as well as the relationship between Cre/BW ratio and skeletal muscle and body fat mass in a multiethnic Malaysian cohort. Methods A total of 13 047 eligible participants were selected from 119 560 The Malaysian Cohort participants. Of these, 750 who developed diabetes were selected as cases, while 3750 controls were chosen randomly from healthy participants. This nested case–control study included 4500 eligible participants from The Malaysian Cohort, with a 1:5 case‐to‐control ratio. Participants were stratified into four groups based on Cre/BW ratio quartiles. The Cox proportional hazards model evaluated the effect of Cre/BW ratio on developing incident diabetes. The association between Cre/BW ratio and body composition was assessed using the Pearson correlation coefficient. Results Of the 13 047 eligible participants followed up over 5.3 years, 5.75% (n = 750) developed diabetes. Diabetes incidence decreased with increasing Cre/BW ratios. The Cre/BW ratio was inversely correlated with diabetes risk (HR: 0.403, 95% CI: 0.315–0.515, p < 0.001). Additionally, males and Indians had a higher risk of developing incident diabetes. A significant correlation was observed between Cre/BW ratio and body fat mass (p < 0.001). Conclusions This study reveals an inverse association between the Cre/BW ratio and incident diabetes. It also found a significant moderate correlation between the Cre/BW ratio and body fat mass.https://doi.org/10.1111/1753-0407.70039body fat massbody weightcreatininediabetesmultiethnic population |
| spellingShingle | Noraidatulakma Abdullah Ying‐Xian Goh Aisyatul Najihah Khuzaimi Azwa Shawani Kamalul Arifin Nurul Ain Mhd Yusuf Nazihah Abd Jalal Norliza Ismail Nurul Faeizah Husin Mohd Arman Kamaruddin Rahman Jamal Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study Journal of Diabetes body fat mass body weight creatinine diabetes multiethnic population |
| title | Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study |
| title_full | Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study |
| title_fullStr | Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study |
| title_full_unstemmed | Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study |
| title_short | Linking Creatinine‐to‐Body Weight Ratio With Diabetes Incidence: A Multiethnic Malaysian Cohort Study |
| title_sort | linking creatinine to body weight ratio with diabetes incidence a multiethnic malaysian cohort study |
| topic | body fat mass body weight creatinine diabetes multiethnic population |
| url | https://doi.org/10.1111/1753-0407.70039 |
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