Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature
Mammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complai...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/656107 |
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| author | Takako Inaba Yuki Fukumura Tsuyoshi Saito Junkichi Yokoyama Shinichi Ohba Atsushi Arakawa Takashi Yao |
| author_facet | Takako Inaba Yuki Fukumura Tsuyoshi Saito Junkichi Yokoyama Shinichi Ohba Atsushi Arakawa Takashi Yao |
| author_sort | Takako Inaba |
| collection | DOAJ |
| description | Mammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complained of a left infra-auricular mass that gradually enlarged for a year. Fine-needle aspiration cytology/imprint cytology showed individual tumor cells that had faintly eosinophilic granular cytoplasm with secretion granules sometimes seen adjacent to the tumor cells. These cytological features overlapped between those of zymogen granule-poor acinic cell carcinoma (AciCC) and MASC. In addition to the case report, we present a review of the related literature with a focus on the cytological features of MASC. The differential diagnostic clues are also discussed. |
| format | Article |
| id | doaj-art-99452cfa1ac34a77996fdab13fba0fb7 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-99452cfa1ac34a77996fdab13fba0fb72025-02-03T01:20:26ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/656107656107Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the LiteratureTakako Inaba0Yuki Fukumura1Tsuyoshi Saito2Junkichi Yokoyama3Shinichi Ohba4Atsushi Arakawa5Takashi Yao6Division of Diagnostic Pathology, Juntendo University, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Human Pathology, Juntendo University School of Medicine, 1-1-19 Motomachi Bldg. 3F, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Human Pathology, Juntendo University School of Medicine, 1-1-19 Motomachi Bldg. 3F, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Otorhinolaryngology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Otorhinolaryngology, Juntendo University School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Human Pathology, Juntendo University School of Medicine, 1-1-19 Motomachi Bldg. 3F, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanDepartment of Human Pathology, Juntendo University School of Medicine, 1-1-19 Motomachi Bldg. 3F, Hongo, Bunkyo-ku, Tokyo 113-0033, JapanMammary analogue secretory carcinoma (MASC) is a recently recognized tumor of salivary glands characterized by the ETV6-NTRK3 fusion gene. This tumor is very rare in children and adolescents. We report a case of MASC in a 15-year-old girl, the fifth youngest case so far reported. The patient complained of a left infra-auricular mass that gradually enlarged for a year. Fine-needle aspiration cytology/imprint cytology showed individual tumor cells that had faintly eosinophilic granular cytoplasm with secretion granules sometimes seen adjacent to the tumor cells. These cytological features overlapped between those of zymogen granule-poor acinic cell carcinoma (AciCC) and MASC. In addition to the case report, we present a review of the related literature with a focus on the cytological features of MASC. The differential diagnostic clues are also discussed.http://dx.doi.org/10.1155/2015/656107 |
| spellingShingle | Takako Inaba Yuki Fukumura Tsuyoshi Saito Junkichi Yokoyama Shinichi Ohba Atsushi Arakawa Takashi Yao Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature Case Reports in Pathology |
| title | Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature |
| title_full | Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature |
| title_fullStr | Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature |
| title_full_unstemmed | Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature |
| title_short | Cytological Features of Mammary Analogue Secretory Carcinoma of the Parotid Gland in a 15-Year-Old Girl: A Case Report with Review of the Literature |
| title_sort | cytological features of mammary analogue secretory carcinoma of the parotid gland in a 15 year old girl a case report with review of the literature |
| url | http://dx.doi.org/10.1155/2015/656107 |
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