Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells
The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate th...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/362163 |
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| author | A. Jiménez-Periáñez B. Abos Gracia J. López Relaño C. M. Diez-Rivero P. A. Reche E. Martínez-Naves E. Matveyeva M. Gómez del Moral |
| author_facet | A. Jiménez-Periáñez B. Abos Gracia J. López Relaño C. M. Diez-Rivero P. A. Reche E. Martínez-Naves E. Matveyeva M. Gómez del Moral |
| author_sort | A. Jiménez-Periáñez |
| collection | DOAJ |
| description | The mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes. |
| format | Article |
| id | doaj-art-99352da545ab43e89f6d59f7d6b85917 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-99352da545ab43e89f6d59f7d6b859172025-02-03T05:43:52ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/362163362163Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic CellsA. Jiménez-Periáñez0B. Abos Gracia1J. López Relaño2C. M. Diez-Rivero3P. A. Reche4E. Martínez-Naves5E. Matveyeva6M. Gómez del Moral7EM-Silicon Nano-Technologies SL, Nat. R. Cisternas 8, 46010 Valencia, SpainImmunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainImmunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainImmunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainImmunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainImmunology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainEM-Silicon Nano-Technologies SL, Nat. R. Cisternas 8, 46010 Valencia, SpainCell Biology Department, Faculty of Medicine, Complutense University, Avenida Complutense s/n, 28040 Madrid, SpainThe mesoporous silicon microparticles (MSMPs) are excellent vehicles for releasing molecules inside the cell. The aim of this work was to use MSMPs to deliver viral specific MHC class I restricted epitopes into human antigen presenting cells (monocyte derived dendritic cells, MDDCs) to facilitate their capture, processing, and presentation to CD8+ (cytotoxic) T lymphocytes. We show for the first time that MSMPs vehiculation of antigenic peptides enhances their MHC class I presentation by human MDDCs to CD8 T lymphocytes.http://dx.doi.org/10.1155/2013/362163 |
| spellingShingle | A. Jiménez-Periáñez B. Abos Gracia J. López Relaño C. M. Diez-Rivero P. A. Reche E. Martínez-Naves E. Matveyeva M. Gómez del Moral Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells Clinical and Developmental Immunology |
| title | Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells |
| title_full | Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells |
| title_fullStr | Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells |
| title_full_unstemmed | Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells |
| title_short | Mesoporous Silicon Microparticles Enhance MHC Class I Cross-Antigen Presentation by Human Dendritic Cells |
| title_sort | mesoporous silicon microparticles enhance mhc class i cross antigen presentation by human dendritic cells |
| url | http://dx.doi.org/10.1155/2013/362163 |
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