Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes
Abstract Non-motor symptoms (NMS) in Parkinson’s disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and...
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| Format: | Article |
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Nature Portfolio
2025-01-01
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| Series: | npj Parkinson's Disease |
| Online Access: | https://doi.org/10.1038/s41531-025-00874-8 |
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| author | Alfonso Enrique Martinez-Nunez Hunter Hutchinson Patricia Coutinho Filipe Pereira Sarmento Venkat Srikar Lavu Qingqi Yuan Jagan Mohan Reddy Dwarampudi Aysegul Gunduz Gregory M. Pontone Michael S. Okun Joshua K. Wong |
| author_facet | Alfonso Enrique Martinez-Nunez Hunter Hutchinson Patricia Coutinho Filipe Pereira Sarmento Venkat Srikar Lavu Qingqi Yuan Jagan Mohan Reddy Dwarampudi Aysegul Gunduz Gregory M. Pontone Michael S. Okun Joshua K. Wong |
| author_sort | Alfonso Enrique Martinez-Nunez |
| collection | DOAJ |
| description | Abstract Non-motor symptoms (NMS) in Parkinson’s disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and cognitive decline. This study explores how early RBD can predict the development of NMS profiles in patients, comparing those with and without early RBD. We identified a unique NMS profile associated with early RBD. These patients had a higher rate of cognitive impairment (M2 = 326.84, p < 0.001), apathy (M2 = 332.93, p < 0.001), hallucinations (M2 = 480.05, p < 0.001), depression (M2 = 480.05, p < 0.0001), anxiety (corrected p < 0.01), impulse control disorders (M2 = 77.577, p < 0.001), and autonomic dysfunction (F = 251.8, p < 0001). A survival analysis revealed an association between early RBD and faster progression to cognitive impairment. These NMS profiles may play a critical role in stratifying patients for targeted interventions. |
| format | Article |
| id | doaj-art-9934ee44a2144f55be31d75a89b5b27f |
| institution | Kabale University |
| issn | 2373-8057 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Parkinson's Disease |
| spelling | doaj-art-9934ee44a2144f55be31d75a89b5b27f2025-02-02T12:13:45ZengNature Portfolionpj Parkinson's Disease2373-80572025-01-011111710.1038/s41531-025-00874-8Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypesAlfonso Enrique Martinez-Nunez0Hunter Hutchinson1Patricia Coutinho2Filipe Pereira Sarmento3Venkat Srikar Lavu4Qingqi Yuan5Jagan Mohan Reddy Dwarampudi6Aysegul Gunduz7Gregory M. Pontone8Michael S. Okun9Joshua K. Wong10Norman Fixel Institute for Neurological Disease, University of FloridaCollege of Medicine, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaCollege of Liberal Arts and Sciences, University of FloridaCollege of Liberal Arts and Sciences, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaNorman Fixel Institute for Neurological Disease, University of FloridaAbstract Non-motor symptoms (NMS) in Parkinson’s disease (PD) significantly impact quality of life, especially in later stages. REM sleep behavior disorder (RBD) affects approximately 42% of all PD patients and frequently precedes motor PD symptoms. RBD is linked to increased rates of depression and cognitive decline. This study explores how early RBD can predict the development of NMS profiles in patients, comparing those with and without early RBD. We identified a unique NMS profile associated with early RBD. These patients had a higher rate of cognitive impairment (M2 = 326.84, p < 0.001), apathy (M2 = 332.93, p < 0.001), hallucinations (M2 = 480.05, p < 0.001), depression (M2 = 480.05, p < 0.0001), anxiety (corrected p < 0.01), impulse control disorders (M2 = 77.577, p < 0.001), and autonomic dysfunction (F = 251.8, p < 0001). A survival analysis revealed an association between early RBD and faster progression to cognitive impairment. These NMS profiles may play a critical role in stratifying patients for targeted interventions.https://doi.org/10.1038/s41531-025-00874-8 |
| spellingShingle | Alfonso Enrique Martinez-Nunez Hunter Hutchinson Patricia Coutinho Filipe Pereira Sarmento Venkat Srikar Lavu Qingqi Yuan Jagan Mohan Reddy Dwarampudi Aysegul Gunduz Gregory M. Pontone Michael S. Okun Joshua K. Wong Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes npj Parkinson's Disease |
| title | Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes |
| title_full | Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes |
| title_fullStr | Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes |
| title_full_unstemmed | Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes |
| title_short | Clinically probable RBD is an early predictor of malignant non-motor Parkinson’s disease phenotypes |
| title_sort | clinically probable rbd is an early predictor of malignant non motor parkinson s disease phenotypes |
| url | https://doi.org/10.1038/s41531-025-00874-8 |
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