Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions
The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic ne...
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| Format: | Article |
| Language: | English |
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Wiley
1999-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/1999/783401 |
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| author | Romana Tomaszewska Krzysztof Okoń Krystyna Nowak Jerzy Stachura |
| author_facet | Romana Tomaszewska Krzysztof Okoń Krystyna Nowak Jerzy Stachura |
| author_sort | Romana Tomaszewska |
| collection | DOAJ |
| description | The increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index) in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia) and high‐grade proliferation (atypical papillary hyperplasia and carcinoma in situ). A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value. |
| format | Article |
| id | doaj-art-991e247874b04c0f94867282f68d7295 |
| institution | Kabale University |
| issn | 0921-8912 1878-3651 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-991e247874b04c0f94867282f68d72952025-02-03T01:20:30ZengWileyAnalytical Cellular Pathology0921-89121878-36511999-01-01193-417518510.1155/1999/783401Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative LesionsRomana Tomaszewska0Krzysztof Okoń1Krystyna Nowak2Jerzy Stachura3Department of Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków, PolandDepartment of Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków, PolandDepartment of Surgery, Collegium Medicum, Jagiellonian University, Kraków, PolandDepartment of Pathomorphology, Collegium Medicum, Jagiellonian University, Kraków, PolandThe increasing frequency and poor prognosis in pancreatic cancer prompt us to search for morphological lesions being a substrate for its development. Studies of autopsy and surgically resected material as well as recent molecular studies have proved that one of the possible pathways of pancreatic neoplasia is the intraepithelial proliferation – dysplasia – cancer sequence. In the present paper we studied the proliferative activity (Ki‐67 index) in pancreatic intraepithelial proliferative lesions and its correlation with geometric features of cell nuclei as signs of increasing dysplasia. The studies were carried out in a group of 35 patients operated on for pancreatic cancer, chronic pancreatitis and other conditions not associated with the pancreas. We used immunohistochemical methods and basic morphometric parameters. The results of our studies indicate that the cell proliferative activity depends both on the type of epithelial proliferation and underlying pancreatic disease. The values of Ki‐67 index are significantly different in low‐grade proliferation (flat and papillary hyperplasia) and high‐grade proliferation (atypical papillary hyperplasia and carcinoma in situ). A set of karyometric features correlates with Ki‐67 index but there is no single feature which would have a diagnostic value.http://dx.doi.org/10.1155/1999/783401 |
| spellingShingle | Romana Tomaszewska Krzysztof Okoń Krystyna Nowak Jerzy Stachura Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions Analytical Cellular Pathology |
| title | Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions |
| title_full | Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions |
| title_fullStr | Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions |
| title_full_unstemmed | Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions |
| title_short | Proliferation Index and Karyometric Features of Pancreatic Intraductal Proliferative Lesions |
| title_sort | proliferation index and karyometric features of pancreatic intraductal proliferative lesions |
| url | http://dx.doi.org/10.1155/1999/783401 |
| work_keys_str_mv | AT romanatomaszewska proliferationindexandkaryometricfeaturesofpancreaticintraductalproliferativelesions AT krzysztofokon proliferationindexandkaryometricfeaturesofpancreaticintraductalproliferativelesions AT krystynanowak proliferationindexandkaryometricfeaturesofpancreaticintraductalproliferativelesions AT jerzystachura proliferationindexandkaryometricfeaturesofpancreaticintraductalproliferativelesions |