Leukocyte Adhesion Molecules in Diabetic Retinopathy
Diabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms underlying the development of DR are not fully und...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2012/279037 |
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| _version_ | 1832555349454880768 |
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| author | Kousuke Noda Shintaro Nakao Susumu Ishida Tatsuro Ishibashi |
| author_facet | Kousuke Noda Shintaro Nakao Susumu Ishida Tatsuro Ishibashi |
| author_sort | Kousuke Noda |
| collection | DOAJ |
| description | Diabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms underlying the development of DR are not fully understood; however, extensive studies have recently implicated chronic, low-grade inflammation in the pathophysiology of DR. During inflammation leukocytes undergo sequential adhesive interactions with endothelial cells to migrate into the inflamed tissues, a process known as the “leukocyte recruitment cascade” which is orchestrated by precise adhesion molecule expression on the cell surface of leukocytes and the endothelium. This paper summarizes the recent clinical and preclinical works on the roles of leukocyte adhesion molecules in DR. |
| format | Article |
| id | doaj-art-9919f9b384614de8979cc268c16e8c13 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-9919f9b384614de8979cc268c16e8c132025-02-03T05:48:26ZengWileyJournal of Ophthalmology2090-004X2090-00582012-01-01201210.1155/2012/279037279037Leukocyte Adhesion Molecules in Diabetic RetinopathyKousuke Noda0Shintaro Nakao1Susumu Ishida2Tatsuro Ishibashi3Laboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, N-15, W-7, Kita-ku, Sapporo 060-8638, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanLaboratory of Ocular Cell Biology and Visual Science, Hokkaido University Graduate School of Medicine, N-15, W-7, Kita-ku, Sapporo 060-8638, JapanDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, JapanDiabetes is a systemic disease that causes a number of metabolic and physiologic abnormalities. One of the major microvascular complications of diabetes is diabetic retinopathy (DR), a leading cause of blindness in people over age 50. The mechanisms underlying the development of DR are not fully understood; however, extensive studies have recently implicated chronic, low-grade inflammation in the pathophysiology of DR. During inflammation leukocytes undergo sequential adhesive interactions with endothelial cells to migrate into the inflamed tissues, a process known as the “leukocyte recruitment cascade” which is orchestrated by precise adhesion molecule expression on the cell surface of leukocytes and the endothelium. This paper summarizes the recent clinical and preclinical works on the roles of leukocyte adhesion molecules in DR.http://dx.doi.org/10.1155/2012/279037 |
| spellingShingle | Kousuke Noda Shintaro Nakao Susumu Ishida Tatsuro Ishibashi Leukocyte Adhesion Molecules in Diabetic Retinopathy Journal of Ophthalmology |
| title | Leukocyte Adhesion Molecules in Diabetic Retinopathy |
| title_full | Leukocyte Adhesion Molecules in Diabetic Retinopathy |
| title_fullStr | Leukocyte Adhesion Molecules in Diabetic Retinopathy |
| title_full_unstemmed | Leukocyte Adhesion Molecules in Diabetic Retinopathy |
| title_short | Leukocyte Adhesion Molecules in Diabetic Retinopathy |
| title_sort | leukocyte adhesion molecules in diabetic retinopathy |
| url | http://dx.doi.org/10.1155/2012/279037 |
| work_keys_str_mv | AT kousukenoda leukocyteadhesionmoleculesindiabeticretinopathy AT shintaronakao leukocyteadhesionmoleculesindiabeticretinopathy AT susumuishida leukocyteadhesionmoleculesindiabeticretinopathy AT tatsuroishibashi leukocyteadhesionmoleculesindiabeticretinopathy |