Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach
Despite the wide range of available colorectal cancer (CRC) screening tests, less than 50% of cases are detected at early stages. However, the identification of differentially expressed proteins or novel protein biomarkers in CRC may have some utility and, ultimately, improve patient care and surviv...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2012/645218 |
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| _version_ | 1832550088651571200 |
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| author | Nai-Jun Fan Chun-Fang Gao Chang-Song Wang Jing-Jing Lv Guang Zhao Xin-Hua Sheng Xiu-Li Wang Dong-Hui Li Qing-Yin Liu Jian Yin |
| author_facet | Nai-Jun Fan Chun-Fang Gao Chang-Song Wang Jing-Jing Lv Guang Zhao Xin-Hua Sheng Xiu-Li Wang Dong-Hui Li Qing-Yin Liu Jian Yin |
| author_sort | Nai-Jun Fan |
| collection | DOAJ |
| description | Despite the wide range of available colorectal cancer (CRC) screening tests, less than 50% of cases are detected at early stages. However, the identification of differentially expressed proteins or novel protein biomarkers in CRC may have some utility and, ultimately, improve patient care and survival. Proteomics combined with mass spectroscopy and liquid chromatography are emerging as powerful tools that have led to the discovery of potential markers in cancer biomarker discovery in several types of cancers. This article describes a novel technology that uses isotopic reagents to tag selected proteins that show a consistent pattern of differential expression in CRC. |
| format | Article |
| id | doaj-art-99153650863b4a70914c87fe90eef659 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-99153650863b4a70914c87fe90eef6592025-02-03T06:07:49ZengWileyCanadian Journal of Gastroenterology0835-79002012-01-01261414710.1155/2012/645218Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics ApproachNai-Jun Fan0Chun-Fang Gao1Chang-Song Wang2Jing-Jing Lv3Guang Zhao4Xin-Hua Sheng5Xiu-Li Wang6Dong-Hui Li7Qing-Yin Liu8Jian Yin9Anal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaDepartment of Pathology, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaAnal-Colorectal Surgery Institute, 150th Hospital of PLA, LuoYang, ChinaDepartment of Clinical Laboratory, 150th Hospital of PLA, LuoYang, ChinaDepartment of Pathology, 150th Hospital of PLA, LuoYang, ChinaDespite the wide range of available colorectal cancer (CRC) screening tests, less than 50% of cases are detected at early stages. However, the identification of differentially expressed proteins or novel protein biomarkers in CRC may have some utility and, ultimately, improve patient care and survival. Proteomics combined with mass spectroscopy and liquid chromatography are emerging as powerful tools that have led to the discovery of potential markers in cancer biomarker discovery in several types of cancers. This article describes a novel technology that uses isotopic reagents to tag selected proteins that show a consistent pattern of differential expression in CRC.http://dx.doi.org/10.1155/2012/645218 |
| spellingShingle | Nai-Jun Fan Chun-Fang Gao Chang-Song Wang Jing-Jing Lv Guang Zhao Xin-Hua Sheng Xiu-Li Wang Dong-Hui Li Qing-Yin Liu Jian Yin Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach Canadian Journal of Gastroenterology |
| title | Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach |
| title_full | Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach |
| title_fullStr | Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach |
| title_full_unstemmed | Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach |
| title_short | Discovery and Verification of Gelsolin as a Potential Biomarker of Colorectal Adenocarcinoma in a Chinese Population: Examining Differential Protein Expression using an Itraq Labelling-Based Proteomics Approach |
| title_sort | discovery and verification of gelsolin as a potential biomarker of colorectal adenocarcinoma in a chinese population examining differential protein expression using an itraq labelling based proteomics approach |
| url | http://dx.doi.org/10.1155/2012/645218 |
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