Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models
Supercritical fluid carbon dioxide extraction technology was developed to gain the active components from a Taiwan native plant, Zingiber officinale (ginger). We studied the biological effects of ginger extracts via multiple assays and demonstrated the biofunctions in each platform. Investigations o...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/210845 |
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| author | Chih-Chen Lee Li-Yu Chiou Jheng-Yang Wang Sin-You Chou John Chi-Wei Lan Tsi-Shu Huang Kuo-Chuan Huang Hui-Min Wang |
| author_facet | Chih-Chen Lee Li-Yu Chiou Jheng-Yang Wang Sin-You Chou John Chi-Wei Lan Tsi-Shu Huang Kuo-Chuan Huang Hui-Min Wang |
| author_sort | Chih-Chen Lee |
| collection | DOAJ |
| description | Supercritical fluid carbon dioxide extraction technology was developed to gain the active components from a Taiwan native plant, Zingiber officinale (ginger). We studied the biological effects of ginger extracts via multiple assays and demonstrated the biofunctions in each platform. Investigations of ginger extracts indicated antioxidative properties in dose-dependant manners on radical scavenging activities, reducing powers and metal chelating powers. We found that ginger extracts processed moderate scavenging values, middle metal chelating levels, and slight ferric reducing powers. The antibacterial susceptibility of ginger extracts on Staphylococcus aureus, Streptococcus sobrinus, S. mutans, and Escherichia coli was determined with the broth microdilution method technique. The ginger extracts had operative antimicroorganism potentials against both Gram-positive and Gram-negative bacteria. We further discovered the strong inhibitions of ginger extracts on lethal carcinogenic melanoma through in vivo xenograft model. To sum up, the data confirmed the possible applications as medical cosmetology agents, pharmaceutical antibiotics, and food supplements. |
| format | Article |
| id | doaj-art-9911fefb1e5b4820951481f085effaf9 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9911fefb1e5b4820951481f085effaf92025-02-03T01:09:28ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/210845210845Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts ModelsChih-Chen Lee0Li-Yu Chiou1Jheng-Yang Wang2Sin-You Chou3John Chi-Wei Lan4Tsi-Shu Huang5Kuo-Chuan Huang6Hui-Min Wang7Department of Chemical Engineering, National Chung Hsing University, Taichung 402, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Chemical Engineering and Materials Science, Yuan Ze University, Taoyuan 32003, TaiwanSection of Microbiology, Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 807, TaiwanDerlin Biotech Corporation, Nantou 540, TaiwanDepartment of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung 807, TaiwanSupercritical fluid carbon dioxide extraction technology was developed to gain the active components from a Taiwan native plant, Zingiber officinale (ginger). We studied the biological effects of ginger extracts via multiple assays and demonstrated the biofunctions in each platform. Investigations of ginger extracts indicated antioxidative properties in dose-dependant manners on radical scavenging activities, reducing powers and metal chelating powers. We found that ginger extracts processed moderate scavenging values, middle metal chelating levels, and slight ferric reducing powers. The antibacterial susceptibility of ginger extracts on Staphylococcus aureus, Streptococcus sobrinus, S. mutans, and Escherichia coli was determined with the broth microdilution method technique. The ginger extracts had operative antimicroorganism potentials against both Gram-positive and Gram-negative bacteria. We further discovered the strong inhibitions of ginger extracts on lethal carcinogenic melanoma through in vivo xenograft model. To sum up, the data confirmed the possible applications as medical cosmetology agents, pharmaceutical antibiotics, and food supplements.http://dx.doi.org/10.1155/2013/210845 |
| spellingShingle | Chih-Chen Lee Li-Yu Chiou Jheng-Yang Wang Sin-You Chou John Chi-Wei Lan Tsi-Shu Huang Kuo-Chuan Huang Hui-Min Wang Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models The Scientific World Journal |
| title | Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models |
| title_full | Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models |
| title_fullStr | Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models |
| title_full_unstemmed | Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models |
| title_short | Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models |
| title_sort | functional ginger extracts from supercritical fluid carbon dioxide extraction via in vitro and in vivo assays antioxidation antimicroorganism and mice xenografts models |
| url | http://dx.doi.org/10.1155/2013/210845 |
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