Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts
Lamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental...
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| Format: | Article |
| Language: | English |
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Sciendo
2019-09-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.2478/acph-2019-0026 |
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| author | Bubueanu Corina Iuksel Rasit Panteli Minerva |
| author_facet | Bubueanu Corina Iuksel Rasit Panteli Minerva |
| author_sort | Bubueanu Corina |
| collection | DOAJ |
| description | Lamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental models in Wistar rats: haemostatic test by tail bleeding time determination and acenocoumarolcarrageenan test. Results of the haemostatic test by tail bleeding determination demonstrated haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the Lamium album extract showed haemostatic activity, comparable to that of vitamin K. Based on the qualitative chemical data on iridoid glycosides (HPTLC), 8-acetylshanzhiside methyl ester might be assumed to be responsible for haemostatic activity. Based on the acute toxicity test, none of the extracts showed toxicity. |
| format | Article |
| id | doaj-art-990c49f40df148428ce7f25edeaab99e |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-990c49f40df148428ce7f25edeaab99e2025-02-02T02:50:42ZengSciendoActa Pharmaceutica1846-95582019-09-0169344344910.2478/acph-2019-0026acph-2019-0026Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial partsBubueanu Corina0Iuksel Rasit1Panteli Minerva2Department of Pharmaceutical Biotechnology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, RomaniaDepartment of Pharmacology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, RomaniaDepartment of Pharmacology, National Institute for Chemical-Pharmaceutical R&D (ICCF-Bucharest), Bucharest, RomaniaLamium album and Lamium purpureum are species belonging to the genus Lamium. Aerial parts of the two species and roots of Lamium album have applications in human and veterinary traditional medicine. Haemostatic properties of butanolic extracts of Lamium species were investigated by two experimental models in Wistar rats: haemostatic test by tail bleeding time determination and acenocoumarolcarrageenan test. Results of the haemostatic test by tail bleeding determination demonstrated haemostatic activity of both extracts. In the acenocoumarol-carrageenan test, only the Lamium album extract showed haemostatic activity, comparable to that of vitamin K. Based on the qualitative chemical data on iridoid glycosides (HPTLC), 8-acetylshanzhiside methyl ester might be assumed to be responsible for haemostatic activity. Based on the acute toxicity test, none of the extracts showed toxicity.https://doi.org/10.2478/acph-2019-0026lamium albumlamium purpureumaerial partsbutanolic extracthaemostatic activitytoxicity |
| spellingShingle | Bubueanu Corina Iuksel Rasit Panteli Minerva Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts Acta Pharmaceutica lamium album lamium purpureum aerial parts butanolic extract haemostatic activity toxicity |
| title | Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts |
| title_full | Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts |
| title_fullStr | Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts |
| title_full_unstemmed | Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts |
| title_short | Haemostatic activity of butanolic extracts of Lamium album and Lamium purpureum aerial parts |
| title_sort | haemostatic activity of butanolic extracts of lamium album and lamium purpureum aerial parts |
| topic | lamium album lamium purpureum aerial parts butanolic extract haemostatic activity toxicity |
| url | https://doi.org/10.2478/acph-2019-0026 |
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