Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation

Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation

Abstract Background Intrahepatic Cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options. Identifying novel therapeutic agents for ICC is crucial. Numerous natural compounds have demonstrated remarkable anti-tumor activities and can enhance the efficacy of chemother...

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Bibliographic Details
Main Authors: Fengyun Zhao, Shuxian Peng, Liming Zou, Mingtian Zhong, Yanni Huang, Ping Wang, Mingfang Ji, Xiaodong Ma, Fugui Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cell Communication and Signaling
Subjects:
Cholangiocarcinoma
Lycorine Hydrochloride
Cholesterol biosynthesis
SQLE
FDFT1
Online Access:https://doi.org/10.1186/s12964-025-02318-5
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