The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation
The medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Pharmacological Sciences |
| Online Access: | http://dx.doi.org/10.1155/2011/157015 |
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| author | Geir Hetland Egil Johnson Torstein Lyberg Gunnar Kvalheim |
| author_facet | Geir Hetland Egil Johnson Torstein Lyberg Gunnar Kvalheim |
| author_sort | Geir Hetland |
| collection | DOAJ |
| description | The medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations. Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation. |
| format | Article |
| id | doaj-art-990a757673de4a4790222953f1bc5019 |
| institution | Kabale University |
| issn | 1687-6334 1687-6342 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Pharmacological Sciences |
| spelling | doaj-art-990a757673de4a4790222953f1bc50192025-02-03T01:10:57ZengWileyAdvances in Pharmacological Sciences1687-63341687-63422011-01-01201110.1155/2011/157015157015The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and InflammationGeir Hetland0Egil Johnson1Torstein Lyberg2Gunnar Kvalheim3Department of Cellular Therapy, The Norwegian Radium Hospital, Oslo University Hospital, Ullernchaussen 70, 0130 Oslo, NorwayDepartment of Gastroenterological Surgery, Ullevål Hospital, Oslo University Hospital, Oslo, NorwayCenter of Clinical Research, Ullevål Hospital, Oslo University Hospital, Oslo, NorwayDepartment of Cellular Therapy, The Norwegian Radium Hospital, Oslo University Hospital, Ullernchaussen 70, 0130 Oslo, NorwayThe medicinal mushroom Agaricus blazei Murill from the Brazilian rain forest has been used in traditional medicine and as health food for the prevention of a range of diseases, including infection, allergy, and cancer. Other scientists and we have examined whether there is scientific evidence behind such postulations. Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.http://dx.doi.org/10.1155/2011/157015 |
| spellingShingle | Geir Hetland Egil Johnson Torstein Lyberg Gunnar Kvalheim The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation Advances in Pharmacological Sciences |
| title | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation |
| title_full | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation |
| title_fullStr | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation |
| title_full_unstemmed | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation |
| title_short | The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation |
| title_sort | mushroom agaricus blazei murill elicits medicinal effects on tumor infection allergy and inflammation through its modulation of innate immunity and amelioration of th1 th2 imbalance and inflammation |
| url | http://dx.doi.org/10.1155/2011/157015 |
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