The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens for carbapenem-resistant Pseudomonas aeruginosa infection: a multicenter real-world and propensity score-matched study

The efficacy and safety of ceftazidime/avibactam or polymyxin B based regimens for carbapenem-resistant Pseudomonas aeruginosa infection: a multicenter real-world and propensity score-matched study

IntroductionCarbapenem-resistant Pseudomonas aeruginosa (CRPA) infections pose a critical clinical challenge. Although ceftazidime/avibactam (CAZ/AVI) and polymyxin B (PMB) are frontline therapies, their comparative effectiveness in terms of 30-day survival, renal safety profiles, and clinical succe...

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Bibliographic Details
Main Authors: Wen-Ming Long, Wei-Xin Xu, Qin Hu, Qiang Qu, Xiao-Li Wu, Ying Chen, Qing Wan, Tian-Tian Xu, Yue Luo, Jian Qu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
ceftazidime/avibactam
polymyxin B
carbapenem-resistant Pseudomonas aeruginosa
real-world study
propensity score-matched
microbiological efficacy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1533952/full
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