Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysisResearch in context

Mazdutide, a dual agonist targeting GLP-1R and GCGR, mitigates diabetes-associated cognitive dysfunction: mechanistic insights from multi-omics analysisResearch in context

Summary: Background: Cognitive impairment and dementia are highly associated with obesity and type 2 diabetes mellitus (T2DM). Recent studies have demonstrated that GLP-1 receptor agonists can improve cognitive function through brain activation in patients with T2DM, compared to other oral glucose-...

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Bibliographic Details
Main Authors: Wanqing Dong, Jie Bai, Qibin Yuan, Yingyu Zhang, Yongjiang Zhang, Ziyue Zhang, Maoxing Yang, Hanxiao Li, Ziyue Zhao, Hongwei Jiang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
Mazdutide
GLP-1R/GCGR dual agonism
Diabetes-associated cognitive dysfunction
db/db mice
Online Access:http://www.sciencedirect.com/science/article/pii/S235239642500235X
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