Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist
Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2013/930354 |
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| author | Mahantesh Namdev Jadhav Ganesh Rajendra Kokil Shilpa Sudhakar Harak Sanjay Baburao Wagh |
| author_facet | Mahantesh Namdev Jadhav Ganesh Rajendra Kokil Shilpa Sudhakar Harak Sanjay Baburao Wagh |
| author_sort | Mahantesh Namdev Jadhav |
| collection | DOAJ |
| description | Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile. Development of novel hybrid atypical tricyclic antipsychotic pharmacophore was achieved using direct (by measuring docking score of designed molecules on modelled 5- receptor) and indirect (current, clinically available therapeutic agents’ data) drug design approaches. |
| format | Article |
| id | doaj-art-98f53dd53ad7425480a9711f7fc00344 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-98f53dd53ad7425480a9711f7fc003442025-02-03T05:50:11ZengWileyJournal of Chemistry2090-90632090-90712013-01-01201310.1155/2013/930354930354Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A AntagonistMahantesh Namdev Jadhav0Ganesh Rajendra Kokil1Shilpa Sudhakar Harak2Sanjay Baburao Wagh3Department of Pharmaceutical Chemistry, MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra 422002, IndiaDepartment of Pharmaceutical Chemistry, Sinhgad Institute of Pharmaceutical Sciences, Kusgaon Budruk, Lonavala, Maharashtra 410401, IndiaDepartment of Pharmaceutical Chemistry, MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra 422002, IndiaDepartment of Pharmaceutical Chemistry, MVP’s College of Pharmacy, Gangapur Road, Nashik, Maharashtra 422002, IndiaSchizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. Given the therapeutic and toxic limitations of clinically available drugs, it is clear that there is still a need for the development of new generation antipsychotic agents with an improved clinical profile. Development of novel hybrid atypical tricyclic antipsychotic pharmacophore was achieved using direct (by measuring docking score of designed molecules on modelled 5- receptor) and indirect (current, clinically available therapeutic agents’ data) drug design approaches.http://dx.doi.org/10.1155/2013/930354 |
| spellingShingle | Mahantesh Namdev Jadhav Ganesh Rajendra Kokil Shilpa Sudhakar Harak Sanjay Baburao Wagh Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist Journal of Chemistry |
| title | Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist |
| title_full | Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist |
| title_fullStr | Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist |
| title_full_unstemmed | Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist |
| title_short | Direct and Indirect Drug Design Approaches for the Development of Novel Tricyclic Antipsychotics: Potential 5-HT2A Antagonist |
| title_sort | direct and indirect drug design approaches for the development of novel tricyclic antipsychotics potential 5 ht2a antagonist |
| url | http://dx.doi.org/10.1155/2013/930354 |
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