Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging
This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small anima...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2016/1947613 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556006148669440 |
|---|---|
| author | Yves Bérubé-Lauzière Matteo Crotti Simon Boucher Seyedrohollah Ettehadi Julien Pichette Ivan Rech |
| author_facet | Yves Bérubé-Lauzière Matteo Crotti Simon Boucher Seyedrohollah Ettehadi Julien Pichette Ivan Rech |
| author_sort | Yves Bérubé-Lauzière |
| collection | DOAJ |
| description | This paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. This data richness is yet to be exploited to its full potential to increase the spatial resolution of DOT imaging and to allow probing, via the fluorescence lifetime, tissue biochemical parameters, and processes that are otherwise not accessible in fluorescence DOT. TD data acquisition time is, however, the main factor that currently compromises the viability of TD-DOT. Current high temporal resolution TD-DOT scanners simply do not integrate sufficient detection channels. Based on our past experience in developing TD-DOT instrumentation, we review and discuss promising technologies to overcome this difficulty. These are single photon avalanche diode (SPAD) detectors and fully parallel highly integrated electronics for time-correlated single photon counting (TCSPC). We present experimental results obtained with such technologies demonstrating the feasibility of next-generation multiview TD-DOT therewith. |
| format | Article |
| id | doaj-art-98e612ada5f04e31beadef214376a9f0 |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-98e612ada5f04e31beadef214376a9f02025-02-03T05:46:40ZengWileyJournal of Spectroscopy2314-49202314-49392016-01-01201610.1155/2016/19476131947613Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal ImagingYves Bérubé-Lauzière0Matteo Crotti1Simon Boucher2Seyedrohollah Ettehadi3Julien Pichette4Ivan Rech5Department of Electrical and Computer Engineering, Université de Sherbrooke, 2500 Boulevard de l’Université, Sherbrooke, QC, J1K 2R1, CanadaDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, ItalyDepartment of Electrical and Computer Engineering, Université de Sherbrooke, 2500 Boulevard de l’Université, Sherbrooke, QC, J1K 2R1, CanadaDepartment of Electrical and Computer Engineering, Université de Sherbrooke, 2500 Boulevard de l’Université, Sherbrooke, QC, J1K 2R1, CanadaDepartment of Electrical and Computer Engineering, Université de Sherbrooke, 2500 Boulevard de l’Université, Sherbrooke, QC, J1K 2R1, CanadaDipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, ItalyThis paper discusses instrumentation based on multiview parallel high temporal resolution (<50 ps) time-domain (TD) measurements for diffuse optical tomography (DOT) and a prospective view on the steps to undertake as regards such instrumentation to make TD-DOT a viable technology for small animal molecular imaging. TD measurements provide information-richest data, and we briefly review the interaction of light with biological tissues to provide an understanding of this. This data richness is yet to be exploited to its full potential to increase the spatial resolution of DOT imaging and to allow probing, via the fluorescence lifetime, tissue biochemical parameters, and processes that are otherwise not accessible in fluorescence DOT. TD data acquisition time is, however, the main factor that currently compromises the viability of TD-DOT. Current high temporal resolution TD-DOT scanners simply do not integrate sufficient detection channels. Based on our past experience in developing TD-DOT instrumentation, we review and discuss promising technologies to overcome this difficulty. These are single photon avalanche diode (SPAD) detectors and fully parallel highly integrated electronics for time-correlated single photon counting (TCSPC). We present experimental results obtained with such technologies demonstrating the feasibility of next-generation multiview TD-DOT therewith.http://dx.doi.org/10.1155/2016/1947613 |
| spellingShingle | Yves Bérubé-Lauzière Matteo Crotti Simon Boucher Seyedrohollah Ettehadi Julien Pichette Ivan Rech Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging Journal of Spectroscopy |
| title | Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging |
| title_full | Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging |
| title_fullStr | Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging |
| title_full_unstemmed | Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging |
| title_short | Prospects on Time-Domain Diffuse Optical Tomography Based on Time-Correlated Single Photon Counting for Small Animal Imaging |
| title_sort | prospects on time domain diffuse optical tomography based on time correlated single photon counting for small animal imaging |
| url | http://dx.doi.org/10.1155/2016/1947613 |
| work_keys_str_mv | AT yvesberubelauziere prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging AT matteocrotti prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging AT simonboucher prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging AT seyedrohollahettehadi prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging AT julienpichette prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging AT ivanrech prospectsontimedomaindiffuseopticaltomographybasedontimecorrelatedsinglephotoncountingforsmallanimalimaging |