Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity
The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learn...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2013/853654 |
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| author | Guy Cheron Bernard Dan Javier Márquez-Ruiz |
| author_facet | Guy Cheron Bernard Dan Javier Márquez-Ruiz |
| author_sort | Guy Cheron |
| collection | DOAJ |
| description | The role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the Purkinje cells specifically controlled by the climbing fiber represents a major element within the feed-forward and feedback loops of the cerebellar cortex. Reciprocally connected with the basal ganglia and multimodal cerebral domains, this cerebellar network may realize fundamental functions in a wide range of behaviors. This review will outline the current understanding of three main experimental paradigms largely used for revealing cerebellar functions in behavioral learning: (1) the vestibuloocular reflex and smooth pursuit control, (2) the eyeblink conditioning, and (3) the sensory envelope plasticity. For each of these experimental conditions, we have critically revisited the chain of causalities linking together neural circuits, neural signals, and plasticity mechanisms, giving preference to behaving or alert animal physiology. Namely, recent experimental approaches mixing neural units and local field potentials recordings have demonstrated a spike timing dependent plasticity by which the cerebellum remains at a strategic crossroad for deciphering fundamental and translational mechanisms from cellular to network levels. |
| format | Article |
| id | doaj-art-98d474190830470fbd73c5cd73158435 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-98d474190830470fbd73c5cd731584352025-02-03T00:59:40ZengWileyNeural Plasticity2090-59041687-54432013-01-01201310.1155/2013/853654853654Translational Approach to Behavioral Learning: Lessons from Cerebellar PlasticityGuy Cheron0Bernard Dan1Javier Márquez-Ruiz2Laboratory of Electrophysiology, Université de Mons, 7000 Mons, BelgiumLaboratory of Neurophysiology and Movement Biomechanics, CP640, ULB Neuroscience Institut, Université Libre de Bruxelles, 1070 Brussels, BelgiumDivisión de Neurociencias, Universidad Pablo de Olavide, 41013 Sevilla, SpainThe role of cerebellar plasticity has been increasingly recognized in learning. The privileged relationship between the cerebellum and the inferior olive offers an ideal circuit for attempting to integrate the numerous evidences of neuronal plasticity into a translational perspective. The high learning capacity of the Purkinje cells specifically controlled by the climbing fiber represents a major element within the feed-forward and feedback loops of the cerebellar cortex. Reciprocally connected with the basal ganglia and multimodal cerebral domains, this cerebellar network may realize fundamental functions in a wide range of behaviors. This review will outline the current understanding of three main experimental paradigms largely used for revealing cerebellar functions in behavioral learning: (1) the vestibuloocular reflex and smooth pursuit control, (2) the eyeblink conditioning, and (3) the sensory envelope plasticity. For each of these experimental conditions, we have critically revisited the chain of causalities linking together neural circuits, neural signals, and plasticity mechanisms, giving preference to behaving or alert animal physiology. Namely, recent experimental approaches mixing neural units and local field potentials recordings have demonstrated a spike timing dependent plasticity by which the cerebellum remains at a strategic crossroad for deciphering fundamental and translational mechanisms from cellular to network levels.http://dx.doi.org/10.1155/2013/853654 |
| spellingShingle | Guy Cheron Bernard Dan Javier Márquez-Ruiz Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity Neural Plasticity |
| title | Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity |
| title_full | Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity |
| title_fullStr | Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity |
| title_full_unstemmed | Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity |
| title_short | Translational Approach to Behavioral Learning: Lessons from Cerebellar Plasticity |
| title_sort | translational approach to behavioral learning lessons from cerebellar plasticity |
| url | http://dx.doi.org/10.1155/2013/853654 |
| work_keys_str_mv | AT guycheron translationalapproachtobehaviorallearninglessonsfromcerebellarplasticity AT bernarddan translationalapproachtobehaviorallearninglessonsfromcerebellarplasticity AT javiermarquezruiz translationalapproachtobehaviorallearninglessonsfromcerebellarplasticity |