Application and progress of 3D printed biomaterials in osteoporosis
Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. Rec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1541746/full |
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| author | Chenxu Wang Chenxu Wang Aiguo Liu Aiguo Liu Ziwen Zhao Ting Ying Shuang Deng Zhen Jian Xu Zhang Chengqing Yi Dejian Li |
| author_facet | Chenxu Wang Chenxu Wang Aiguo Liu Aiguo Liu Ziwen Zhao Ting Ying Shuang Deng Zhen Jian Xu Zhang Chengqing Yi Dejian Li |
| author_sort | Chenxu Wang |
| collection | DOAJ |
| description | Osteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention as promising alternatives for managing osteoporosis. This review summarizes the current advancements in 3D-printed biomaterials designed for osteoporosis treatment. The benefits of biomaterial-based approaches compared to traditional systemic drug therapies are discussed. These 3D-printed materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, and inhibiting osteoclast activity. 3D printing has the advantages of speed, precision, personalization, etc. It is able to satisfy the requirements of irregular geometry, differentiated composition, and multilayered structure of articular osteochondral scaffolds with boundary layer structure. The limitations of existing biomaterials are critically analyzed and future directions for biomaterial-based therapies are considered. |
| format | Article |
| id | doaj-art-98d05041376a47858a15dfa8fa808c7b |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-98d05041376a47858a15dfa8fa808c7b2025-02-04T06:31:54ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15417461541746Application and progress of 3D printed biomaterials in osteoporosisChenxu Wang0Chenxu Wang1Aiguo Liu2Aiguo Liu3Ziwen Zhao4Ting Ying5Shuang Deng6Zhen Jian7Xu Zhang8Chengqing Yi9Dejian Li10Department of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Henan University, Kaifeng, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, ChinaOsteoporosis results from a disruption in skeletal homeostasis caused by an imbalance between bone resorption and bone formation. Conventional treatments, such as pharmaceutical drugs and hormone replacement therapy, often yield suboptimal results and are frequently associated with side effects. Recently, biomaterial-based approaches have gained attention as promising alternatives for managing osteoporosis. This review summarizes the current advancements in 3D-printed biomaterials designed for osteoporosis treatment. The benefits of biomaterial-based approaches compared to traditional systemic drug therapies are discussed. These 3D-printed materials can be broadly categorized based on their functionalities, including promoting osteogenesis, reducing inflammation, exhibiting antioxidant properties, and inhibiting osteoclast activity. 3D printing has the advantages of speed, precision, personalization, etc. It is able to satisfy the requirements of irregular geometry, differentiated composition, and multilayered structure of articular osteochondral scaffolds with boundary layer structure. The limitations of existing biomaterials are critically analyzed and future directions for biomaterial-based therapies are considered.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1541746/full3D printingbiomaterialsosteoporosisreactive oxygen speciesbone |
| spellingShingle | Chenxu Wang Chenxu Wang Aiguo Liu Aiguo Liu Ziwen Zhao Ting Ying Shuang Deng Zhen Jian Xu Zhang Chengqing Yi Dejian Li Application and progress of 3D printed biomaterials in osteoporosis Frontiers in Bioengineering and Biotechnology 3D printing biomaterials osteoporosis reactive oxygen species bone |
| title | Application and progress of 3D printed biomaterials in osteoporosis |
| title_full | Application and progress of 3D printed biomaterials in osteoporosis |
| title_fullStr | Application and progress of 3D printed biomaterials in osteoporosis |
| title_full_unstemmed | Application and progress of 3D printed biomaterials in osteoporosis |
| title_short | Application and progress of 3D printed biomaterials in osteoporosis |
| title_sort | application and progress of 3d printed biomaterials in osteoporosis |
| topic | 3D printing biomaterials osteoporosis reactive oxygen species bone |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1541746/full |
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