Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury
Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and ex...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/1279051 |
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| _version_ | 1832565596935421952 |
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| author | Ping Li Zhao-Qian Teng Chang-Mei Liu |
| author_facet | Ping Li Zhao-Qian Teng Chang-Mei Liu |
| author_sort | Ping Li |
| collection | DOAJ |
| description | Spinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration after injury. MicroRNAs can modulate multiple genes’ expression and are tightly controlled during nerve development or the injury process. Evidence has demonstrated that microRNAs and their signaling pathways play important roles in mediating axon regeneration and glial scar formation after spinal cord injury. This article reviews the role and mechanism of differentially expressed microRNAs in regulating axon regeneration and glial scar formation after spinal cord injury, as well as their therapeutic potential for promoting axonal regeneration and repair of the injured spinal cord. |
| format | Article |
| id | doaj-art-98c80bd73e5644448ee61514bee80ec4 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-98c80bd73e5644448ee61514bee80ec42025-02-03T01:07:10ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/12790511279051Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord InjuryPing Li0Zhao-Qian Teng1Chang-Mei Liu2State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaState Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, ChinaSpinal cord injury is a devastating disease which disrupts the connections between the brain and spinal cord, often resulting in the loss of sensory and motor function below the lesion site. Most injured neurons fail to regenerate in the central nervous system after injury. Multiple intrinsic and extrinsic factors contribute to the general failure of axonal regeneration after injury. MicroRNAs can modulate multiple genes’ expression and are tightly controlled during nerve development or the injury process. Evidence has demonstrated that microRNAs and their signaling pathways play important roles in mediating axon regeneration and glial scar formation after spinal cord injury. This article reviews the role and mechanism of differentially expressed microRNAs in regulating axon regeneration and glial scar formation after spinal cord injury, as well as their therapeutic potential for promoting axonal regeneration and repair of the injured spinal cord.http://dx.doi.org/10.1155/2016/1279051 |
| spellingShingle | Ping Li Zhao-Qian Teng Chang-Mei Liu Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury Neural Plasticity |
| title | Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury |
| title_full | Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury |
| title_fullStr | Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury |
| title_full_unstemmed | Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury |
| title_short | Extrinsic and Intrinsic Regulation of Axon Regeneration by MicroRNAs after Spinal Cord Injury |
| title_sort | extrinsic and intrinsic regulation of axon regeneration by micrornas after spinal cord injury |
| url | http://dx.doi.org/10.1155/2016/1279051 |
| work_keys_str_mv | AT pingli extrinsicandintrinsicregulationofaxonregenerationbymicrornasafterspinalcordinjury AT zhaoqianteng extrinsicandintrinsicregulationofaxonregenerationbymicrornasafterspinalcordinjury AT changmeiliu extrinsicandintrinsicregulationofaxonregenerationbymicrornasafterspinalcordinjury |