Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2011/717130 |
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| author | E. Bargagli A. Prasse C. Olivieri J. Muller-Quernheim P. Rottoli |
| author_facet | E. Bargagli A. Prasse C. Olivieri J. Muller-Quernheim P. Rottoli |
| author_sort | E. Bargagli |
| collection | DOAJ |
| description | Idiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators in the pathogenesis of IPF was recently documented. This paper focuses on recent literature on potential biomarkers of IPF derived from activated alveolar macrophages. Biomarker discovery and clinical application are a recent topic of interest in the field of interstitial lung diseases (ILDs). Cytokines, CC-chemokines, and other macrophage-produced mediators are the most promising prognostic biomarkers. Many molecules have been proposed in the literature as potential biomarker of IPF; however, a rigorous validation is needed to confirm their clinical utility. |
| format | Article |
| id | doaj-art-98c5f0bab9ef4dfca117dc1d2d118fa1 |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-98c5f0bab9ef4dfca117dc1d2d118fa12025-02-03T05:46:40ZengWileyPulmonary Medicine2090-18362090-18442011-01-01201110.1155/2011/717130717130Macrophage-Derived Biomarkers of Idiopathic Pulmonary FibrosisE. Bargagli0A. Prasse1C. Olivieri2J. Muller-Quernheim3P. Rottoli4Respiratory Diseases Section, Siena University, 53100 Siena, ItalyDepartment of Pneumology, Freiburg University, GermanyRespiratory Diseases Section, Siena University, 53100 Siena, ItalyDepartment of Pneumology, Freiburg University, GermanyRespiratory Diseases Section, Siena University, 53100 Siena, ItalyIdiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators in the pathogenesis of IPF was recently documented. This paper focuses on recent literature on potential biomarkers of IPF derived from activated alveolar macrophages. Biomarker discovery and clinical application are a recent topic of interest in the field of interstitial lung diseases (ILDs). Cytokines, CC-chemokines, and other macrophage-produced mediators are the most promising prognostic biomarkers. Many molecules have been proposed in the literature as potential biomarker of IPF; however, a rigorous validation is needed to confirm their clinical utility.http://dx.doi.org/10.1155/2011/717130 |
| spellingShingle | E. Bargagli A. Prasse C. Olivieri J. Muller-Quernheim P. Rottoli Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis Pulmonary Medicine |
| title | Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis |
| title_full | Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis |
| title_fullStr | Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis |
| title_full_unstemmed | Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis |
| title_short | Macrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis |
| title_sort | macrophage derived biomarkers of idiopathic pulmonary fibrosis |
| url | http://dx.doi.org/10.1155/2011/717130 |
| work_keys_str_mv | AT ebargagli macrophagederivedbiomarkersofidiopathicpulmonaryfibrosis AT aprasse macrophagederivedbiomarkersofidiopathicpulmonaryfibrosis AT colivieri macrophagederivedbiomarkersofidiopathicpulmonaryfibrosis AT jmullerquernheim macrophagederivedbiomarkersofidiopathicpulmonaryfibrosis AT prottoli macrophagederivedbiomarkersofidiopathicpulmonaryfibrosis |