HDR Brachytherapy in the Management of High-Risk Prostate Cancer
High-dose-rate (HDR) brachytherapy is used with increasing frequency for the treatment of prostate cancer. It is a technique which allows delivery of large individual fractions to the prostate without exposing adjacent normal tissues to unacceptable toxicity. This approach is particularly favourable...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Advances in Urology |
| Online Access: | http://dx.doi.org/10.1155/2012/980841 |
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| _version_ | 1832553209940410368 |
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| author | Susan Masson Raj Persad Amit Bahl |
| author_facet | Susan Masson Raj Persad Amit Bahl |
| author_sort | Susan Masson |
| collection | DOAJ |
| description | High-dose-rate (HDR) brachytherapy is used with increasing frequency for the treatment of prostate cancer. It is a technique which allows delivery of large individual fractions to the prostate without exposing adjacent normal tissues to unacceptable toxicity. This approach is particularly favourable in prostate cancer where tumours are highly sensitive to dose escalation and to increases in radiotherapy fraction size, due to the unique radiobiological behaviour of prostate cancers in contrast with other malignancies. In this paper we discuss the rationale and the increasing body of clinical evidence for the use of this technique in patients with high-risk prostate cancer, where it is combined with external beam radiotherapy. We highlight practical aspects of delivering treatment and discuss toxicity and limitations, with particular reference to current practice in the United Kingdom. |
| format | Article |
| id | doaj-art-98c415397e8340cb96f303f4c37e553c |
| institution | Kabale University |
| issn | 1687-6369 1687-6377 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Urology |
| spelling | doaj-art-98c415397e8340cb96f303f4c37e553c2025-02-03T05:55:16ZengWileyAdvances in Urology1687-63691687-63772012-01-01201210.1155/2012/980841980841HDR Brachytherapy in the Management of High-Risk Prostate CancerSusan Masson0Raj Persad1Amit Bahl2Bristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8ED, UKDepartment of Urology, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8HW, UKBristol Haematology and Oncology Centre, University Hospitals Bristol NHS Foundation Trust, Bristol BS2 8ED, UKHigh-dose-rate (HDR) brachytherapy is used with increasing frequency for the treatment of prostate cancer. It is a technique which allows delivery of large individual fractions to the prostate without exposing adjacent normal tissues to unacceptable toxicity. This approach is particularly favourable in prostate cancer where tumours are highly sensitive to dose escalation and to increases in radiotherapy fraction size, due to the unique radiobiological behaviour of prostate cancers in contrast with other malignancies. In this paper we discuss the rationale and the increasing body of clinical evidence for the use of this technique in patients with high-risk prostate cancer, where it is combined with external beam radiotherapy. We highlight practical aspects of delivering treatment and discuss toxicity and limitations, with particular reference to current practice in the United Kingdom.http://dx.doi.org/10.1155/2012/980841 |
| spellingShingle | Susan Masson Raj Persad Amit Bahl HDR Brachytherapy in the Management of High-Risk Prostate Cancer Advances in Urology |
| title | HDR Brachytherapy in the Management of High-Risk Prostate Cancer |
| title_full | HDR Brachytherapy in the Management of High-Risk Prostate Cancer |
| title_fullStr | HDR Brachytherapy in the Management of High-Risk Prostate Cancer |
| title_full_unstemmed | HDR Brachytherapy in the Management of High-Risk Prostate Cancer |
| title_short | HDR Brachytherapy in the Management of High-Risk Prostate Cancer |
| title_sort | hdr brachytherapy in the management of high risk prostate cancer |
| url | http://dx.doi.org/10.1155/2012/980841 |
| work_keys_str_mv | AT susanmasson hdrbrachytherapyinthemanagementofhighriskprostatecancer AT rajpersad hdrbrachytherapyinthemanagementofhighriskprostatecancer AT amitbahl hdrbrachytherapyinthemanagementofhighriskprostatecancer |