Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis
Vitamin D is commonly recommended for daily intake as dietary sources are often insufficient. However, prolonged high-dose use can lead to serious complications. We present a rare case of a 2-month-old infant who developed severe hypercalcemia and hypertriglyceridemia due to an accidental overdose o...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2025-01-01
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| Series: | Endocrinology, Diabetes & Metabolism Case Reports |
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| Online Access: | https://edm.bioscientifica.com/view/journals/edm/2025/1/EDM-24-0132.xml |
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| author | Bushra Rehman Fozia Memon Khadija Nuzhat Humayun Muzna Arif |
| author_facet | Bushra Rehman Fozia Memon Khadija Nuzhat Humayun Muzna Arif |
| author_sort | Bushra Rehman |
| collection | DOAJ |
| description | Vitamin D is commonly recommended for daily intake as dietary sources are often insufficient. However, prolonged high-dose use can lead to serious complications. We present a rare case of a 2-month-old infant who developed severe hypercalcemia and hypertriglyceridemia due to an accidental overdose of 25-OH vitamin D, leading to hypertriglyceridemia and pancreatitis. The management challenges encountered while managing this case were the need for high glucose infusion rate fluids with insulin for hypertriglyceridemia, electrolyte imbalances secondary to forced diuresis, difficulties in providing fat-free formula, gradual introduction of maternal breastfeeding due to pancreatitis and rebound hypercalcemia requiring steroid treatment. These complications, rarely reported in hypervitaminosis D, highlight the need for careful vitamin D dosing in the pediatric population. Potential areas leading to vitamin D intoxication include improper formulation, lack of clarity in prescribing, concurrent use of other vitamin D-containing supplements, parental access to the internet for health supplements and easy availability. |
| format | Article |
| id | doaj-art-98ae3f38fc7d43a4a6bfa9ca3b105505 |
| institution | Kabale University |
| issn | 2052-0573 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism Case Reports |
| spelling | doaj-art-98ae3f38fc7d43a4a6bfa9ca3b1055052025-02-05T10:18:32ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732025-01-012025110.1530/EDM-24-01321Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitisBushra Rehman0Fozia Memon1Khadija Nuzhat Humayun2Muzna Arif3Department of Pediatrics and Child Health, The Aga Khan University Hospital, Karachi, PakistanDepartment of Pediatrics and Child Health, The Aga Khan University Hospital, Karachi, PakistanDepartment of Pediatrics and Child Health, The Aga Khan University Hospital, Karachi, PakistanDepartment of Pediatrics and Child Health, The Aga Khan University Hospital, Karachi, PakistanVitamin D is commonly recommended for daily intake as dietary sources are often insufficient. However, prolonged high-dose use can lead to serious complications. We present a rare case of a 2-month-old infant who developed severe hypercalcemia and hypertriglyceridemia due to an accidental overdose of 25-OH vitamin D, leading to hypertriglyceridemia and pancreatitis. The management challenges encountered while managing this case were the need for high glucose infusion rate fluids with insulin for hypertriglyceridemia, electrolyte imbalances secondary to forced diuresis, difficulties in providing fat-free formula, gradual introduction of maternal breastfeeding due to pancreatitis and rebound hypercalcemia requiring steroid treatment. These complications, rarely reported in hypervitaminosis D, highlight the need for careful vitamin D dosing in the pediatric population. Potential areas leading to vitamin D intoxication include improper formulation, lack of clarity in prescribing, concurrent use of other vitamin D-containing supplements, parental access to the internet for health supplements and easy availability.https://edm.bioscientifica.com/view/journals/edm/2025/1/EDM-24-0132.xmlvitamin d intoxicationpediatric endocrinologypancreatitishypertriglyceridemia |
| spellingShingle | Bushra Rehman Fozia Memon Khadija Nuzhat Humayun Muzna Arif Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis Endocrinology, Diabetes & Metabolism Case Reports vitamin d intoxication pediatric endocrinology pancreatitis hypertriglyceridemia |
| title | Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis |
| title_full | Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis |
| title_fullStr | Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis |
| title_full_unstemmed | Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis |
| title_short | Rare presentation of vitamin D toxicity with hypertriglyceridemia and pancreatitis |
| title_sort | rare presentation of vitamin d toxicity with hypertriglyceridemia and pancreatitis |
| topic | vitamin d intoxication pediatric endocrinology pancreatitis hypertriglyceridemia |
| url | https://edm.bioscientifica.com/view/journals/edm/2025/1/EDM-24-0132.xml |
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