Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach
The current study was carried out to compare total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities of extracts/ fractions of nine medicinal plants including Quercus infectoria (QI), Fagonia arabica (FA), Embelia ribes (ER), Cichorium intybus (CI), Ipomoea nil (IN),...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715624006568 |
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| author | Faiza Imtiaz Dildar Ahmed Osama A. Mohammed Umer Younas Munawar Iqbal |
| author_facet | Faiza Imtiaz Dildar Ahmed Osama A. Mohammed Umer Younas Munawar Iqbal |
| author_sort | Faiza Imtiaz |
| collection | DOAJ |
| description | The current study was carried out to compare total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities of extracts/ fractions of nine medicinal plants including Quercus infectoria (QI), Fagonia arabica (FA), Embelia ribes (ER), Cichorium intybus (CI), Ipomoea nil (IN), Acacia nilotica (AN), Psoralea corylifolia (PC), Tinospora cordifolia (TC), and Thuja orientalis (TO). Chloroform and ethyl acetate fractions obtained from QI, ER, AN, PC, and TO were found to have the highest phenolic/flavonoid content and antioxidant index values. The chloroform fraction of QI exhibited the highest DPPH and ABTS activities with 77.63% and 97.94%, respectively. Based on these results, the three highest-ranked plant extracts were further investigated using a simplex centroid mixture design. The optimal blend, consisting of 69% QI, 12% TO, and 19% ER, resulted in maximized values for TPC (292.36 mg GAE/g DW), TFC (65.21 mg RE/g DW), and DPPH (90.44%). This study highlights the development of optimized plant extract mixtures as a natural therapeutic strategy specifically designed to combat oxidative stress-related diseases, offering a potential alternative to conventional treatments. |
| format | Article |
| id | doaj-art-98a5f303eec24c02b9c663f0dd33fc31 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-98a5f303eec24c02b9c663f0dd33fc312025-01-29T05:00:42ZengElsevierResults in Chemistry2211-71562025-01-0113101960Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approachFaiza Imtiaz0Dildar Ahmed1Osama A. Mohammed2Umer Younas3Munawar Iqbal4Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54000, Pakistan; Department of Chemistry, The University of Lahore, Lahore 54000, PakistanDepartment of Chemistry, Forman Christian College (A Chartered University), Lahore 54000, Pakistan; Correspondence authors.Department of Pharmacology, College of Medicine, University of Bisha, Bisha 61922, Saudi ArabiaDepartment of Chemistry, The University of Lahore, Lahore 54000, Pakistan; Correspondence authors.School of Chemistry, University of the Punjab, Lahore 54590, PakistanThe current study was carried out to compare total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activities of extracts/ fractions of nine medicinal plants including Quercus infectoria (QI), Fagonia arabica (FA), Embelia ribes (ER), Cichorium intybus (CI), Ipomoea nil (IN), Acacia nilotica (AN), Psoralea corylifolia (PC), Tinospora cordifolia (TC), and Thuja orientalis (TO). Chloroform and ethyl acetate fractions obtained from QI, ER, AN, PC, and TO were found to have the highest phenolic/flavonoid content and antioxidant index values. The chloroform fraction of QI exhibited the highest DPPH and ABTS activities with 77.63% and 97.94%, respectively. Based on these results, the three highest-ranked plant extracts were further investigated using a simplex centroid mixture design. The optimal blend, consisting of 69% QI, 12% TO, and 19% ER, resulted in maximized values for TPC (292.36 mg GAE/g DW), TFC (65.21 mg RE/g DW), and DPPH (90.44%). This study highlights the development of optimized plant extract mixtures as a natural therapeutic strategy specifically designed to combat oxidative stress-related diseases, offering a potential alternative to conventional treatments.http://www.sciencedirect.com/science/article/pii/S2211715624006568AntioxidantMedicinal plantsAntiviral compoundsPrincipal component analysisMixture design analysis |
| spellingShingle | Faiza Imtiaz Dildar Ahmed Osama A. Mohammed Umer Younas Munawar Iqbal Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach Results in Chemistry Antioxidant Medicinal plants Antiviral compounds Principal component analysis Mixture design analysis |
| title | Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach |
| title_full | Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach |
| title_fullStr | Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach |
| title_full_unstemmed | Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach |
| title_short | Optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity: A mixture design approach |
| title_sort | optimized recovery of phenolic and flavonoid compounds from medicinal plant extracts for enhanced antioxidant activity a mixture design approach |
| topic | Antioxidant Medicinal plants Antiviral compounds Principal component analysis Mixture design analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2211715624006568 |
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