Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm frequently complicated by transfusion dependent anemia. Both anemia and transfusion-dependence are associated with a poor outcome, at least in part because of toxic effects of iron overload (IOL). Iron-chelating therapy (ICT) is increasing...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/520712 |
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| _version_ | 1832562120785395712 |
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| author | Del Corso Lisette Balleari Enrico Arboscello Eleonora Ghio Riccardo Mencoboni Manlio Racchi Omar |
| author_facet | Del Corso Lisette Balleari Enrico Arboscello Eleonora Ghio Riccardo Mencoboni Manlio Racchi Omar |
| author_sort | Del Corso Lisette |
| collection | DOAJ |
| description | Primary myelofibrosis (PMF) is a myeloproliferative neoplasm frequently complicated by transfusion dependent anemia. Both anemia and transfusion-dependence are associated with a poor outcome, at least in part because of toxic effects of iron overload (IOL). Iron-chelating therapy (ICT) is increasingly used in order to prevent IOL in this setting. Here, we describe the case of a 73-year-old man affected by PMF and severe transfusion-dependent anemia who experienced a dramatic erythroid response after being treated with deferasirox to prevent IOL. |
| format | Article |
| id | doaj-art-98a573e5b99342b5a7f7331c47f81820 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-98a573e5b99342b5a7f7331c47f818202025-02-03T01:23:25ZengWileyCase Reports in Hematology2090-65602090-65792013-01-01201310.1155/2013/520712520712Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary MyelofibrosisDel Corso Lisette0Balleari Enrico1Arboscello Eleonora2Ghio Riccardo3Mencoboni Manlio4Racchi Omar5Department of Hematology and Oncology, IRCCS AOU San Martino-IST, Largo Rosanna Benzi 10, 16132 Genoa, ItalyDepartment of Hematology and Oncology, IRCCS AOU San Martino-IST, Largo Rosanna Benzi 10, 16132 Genoa, ItalyDepartment of Hematology and Oncology, IRCCS AOU San Martino-IST, Largo Rosanna Benzi 10, 16132 Genoa, ItalyDepartment of Hematology and Oncology, IRCCS AOU San Martino-IST, Largo Rosanna Benzi 10, 16132 Genoa, ItalyDepartment of Oncology, Villa Scassi Hospital, ASL 3, Corso Scassi, 16151 Genoa, ItalyDepartment of Oncology, Villa Scassi Hospital, ASL 3, Corso Scassi, 16151 Genoa, ItalyPrimary myelofibrosis (PMF) is a myeloproliferative neoplasm frequently complicated by transfusion dependent anemia. Both anemia and transfusion-dependence are associated with a poor outcome, at least in part because of toxic effects of iron overload (IOL). Iron-chelating therapy (ICT) is increasingly used in order to prevent IOL in this setting. Here, we describe the case of a 73-year-old man affected by PMF and severe transfusion-dependent anemia who experienced a dramatic erythroid response after being treated with deferasirox to prevent IOL.http://dx.doi.org/10.1155/2013/520712 |
| spellingShingle | Del Corso Lisette Balleari Enrico Arboscello Eleonora Ghio Riccardo Mencoboni Manlio Racchi Omar Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis Case Reports in Hematology |
| title | Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis |
| title_full | Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis |
| title_fullStr | Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis |
| title_full_unstemmed | Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis |
| title_short | Mayor Erythropoietic Response after Deferasirox Treatment in a Transfusion-Dependent Anemic Patient with Primary Myelofibrosis |
| title_sort | mayor erythropoietic response after deferasirox treatment in a transfusion dependent anemic patient with primary myelofibrosis |
| url | http://dx.doi.org/10.1155/2013/520712 |
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