PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese
The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2021/8880042 |
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| author | Glêbia A. Cardoso Mateus D. Ribeiro Bruno R. V. Sousa Yohanna de Oliveira Klécia F. Sena Joane R. E. Batista Antônio E. M. Almeida João M. Filho Raquel S. B. Silva Darlene C. Persuhn Alexandre S. Silva |
| author_facet | Glêbia A. Cardoso Mateus D. Ribeiro Bruno R. V. Sousa Yohanna de Oliveira Klécia F. Sena Joane R. E. Batista Antônio E. M. Almeida João M. Filho Raquel S. B. Silva Darlene C. Persuhn Alexandre S. Silva |
| author_sort | Glêbia A. Cardoso |
| collection | DOAJ |
| description | The objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program. Fifty-eight previously inactive men and women, body mass index (BMI) 31.5±2.8 kg/m2, 46.5% (n=27) genotyped as CC genotype and 53.5% (n=31) as CA+AA, underwent a 12-week aerobic training (walking/running). Aerobic capacity (ergospirometry), body composition (DXA), and nutritional assessment were made before and 48 h after the experimental protocol. Two-way ANOVA, chi-square test, and logistic regression were used (p<0.05). Twenty-seven volunteers (46.5%) were identified as CC genotype and 31 (53.5%) as CA+AA genotype. Time-group interaction showed that there was no difference in these between two allele groups. However, differences in distribution of respondents or nonresponders according to allele A were identified for fat mass (p≤0.003), percentage fat mass (p≤0.002), the waist (p≤0.009), abdomen (p≤0.000), and hip (p≤0.001), this difference being independent for the fat mass. Meanwhile, sex, age, and nutritional management have also been found to be influential factors. It is concluded that the PPARα gene is involved in varying body composition in response to an aerobic training program. |
| format | Article |
| id | doaj-art-9898aa227da44e9c8de7e15c348bdb9b |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-9898aa227da44e9c8de7e15c348bdb9b2025-02-03T05:44:51ZengWileyPPAR Research1687-47571687-47652021-01-01202110.1155/2021/88800428880042PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/ObeseGlêbia A. Cardoso0Mateus D. Ribeiro1Bruno R. V. Sousa2Yohanna de Oliveira3Klécia F. Sena4Joane R. E. Batista5Antônio E. M. Almeida6João M. Filho7Raquel S. B. Silva8Darlene C. Persuhn9Alexandre S. Silva10Laboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilGraduate Program in Nutrition Sciences, Department of Nutrition, Federal University of Paraíba-PPGCN/UFPB, João Pessoa, CEP: 58051-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilLauro Wanderley University Hospital-HULW-Federal University of Paraíba-UFPB, João Pessoa, CEP: 58059-900 Paraíba, BrazilLauro Wanderley University Hospital-HULW-Federal University of Paraíba-UFPB, João Pessoa, CEP: 58059-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilGraduate Program in Nutrition Sciences, Department of Nutrition, Federal University of Paraíba-PPGCN/UFPB, João Pessoa, CEP: 58051-900 Paraíba, BrazilLaboratory of Applied Studies in Physical Training to Performance and Health-LETFADS, Department of Physical Education, Federal University of Paraíba, João Pessoa, CEP: 58059-900 Paraíba, BrazilThe objective of this study was to investigate the relationship of the polymorphism in Intron 7 G/C (rs 4253778) of the peroxisome proliferator-activated receptor alpha (PPARα) gene with the magnitude of changes in the body composition of an overweight and obese population that underwent an aerobic training program. Fifty-eight previously inactive men and women, body mass index (BMI) 31.5±2.8 kg/m2, 46.5% (n=27) genotyped as CC genotype and 53.5% (n=31) as CA+AA, underwent a 12-week aerobic training (walking/running). Aerobic capacity (ergospirometry), body composition (DXA), and nutritional assessment were made before and 48 h after the experimental protocol. Two-way ANOVA, chi-square test, and logistic regression were used (p<0.05). Twenty-seven volunteers (46.5%) were identified as CC genotype and 31 (53.5%) as CA+AA genotype. Time-group interaction showed that there was no difference in these between two allele groups. However, differences in distribution of respondents or nonresponders according to allele A were identified for fat mass (p≤0.003), percentage fat mass (p≤0.002), the waist (p≤0.009), abdomen (p≤0.000), and hip (p≤0.001), this difference being independent for the fat mass. Meanwhile, sex, age, and nutritional management have also been found to be influential factors. It is concluded that the PPARα gene is involved in varying body composition in response to an aerobic training program.http://dx.doi.org/10.1155/2021/8880042 |
| spellingShingle | Glêbia A. Cardoso Mateus D. Ribeiro Bruno R. V. Sousa Yohanna de Oliveira Klécia F. Sena Joane R. E. Batista Antônio E. M. Almeida João M. Filho Raquel S. B. Silva Darlene C. Persuhn Alexandre S. Silva PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese PPAR Research |
| title | PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese |
| title_full | PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese |
| title_fullStr | PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese |
| title_full_unstemmed | PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese |
| title_short | PPARα Gene Is Involved in Body Composition Variation in Response to an Aerobic Training Program in Overweight/Obese |
| title_sort | pparα gene is involved in body composition variation in response to an aerobic training program in overweight obese |
| url | http://dx.doi.org/10.1155/2021/8880042 |
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