Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report
This is a case presentation of a primary central nervous system B-cell lymphoma in a 69-year-old woman with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and chronic immunosuppressive treatment. The patient had been diagnosed as having probable chronic...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2025-01-01
|
| Series: | SAGE Open Medical Case Reports |
| Online Access: | https://doi.org/10.1177/2050313X251316764 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832577757426483200 |
|---|---|
| author | Evangelos Koumasopoulos Evangelia-Anna Spiteri Aigli G Vakrakou Panagiotis Toulas Georgios Velonakis George Stranjalis Leonidas Stefanis Maria-Eleptheria Evangelopoulos Maria Anagnostouli |
| author_facet | Evangelos Koumasopoulos Evangelia-Anna Spiteri Aigli G Vakrakou Panagiotis Toulas Georgios Velonakis George Stranjalis Leonidas Stefanis Maria-Eleptheria Evangelopoulos Maria Anagnostouli |
| author_sort | Evangelos Koumasopoulos |
| collection | DOAJ |
| description | This is a case presentation of a primary central nervous system B-cell lymphoma in a 69-year-old woman with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and chronic immunosuppressive treatment. The patient had been diagnosed as having probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, according to international criteria. Afterward, regular clinical and imaging examinations and blood tests were performed. The patient presented with primary central nervous system B-cell lymphoma 3 years after the initial diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Brain tissue histology was indicative of diffuse giant B cells, Epstein–Barr virus positive, and non-Hodgkin lymphoma. The nature of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is obscure, driving the formulation of many hypotheses about its causes. In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and/or along with Epstein–Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. Further research is needed and close monitoring of such patients is strongly recommended. |
| format | Article |
| id | doaj-art-98968906043440ceb561b4ffe1f09447 |
| institution | Kabale University |
| issn | 2050-313X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medical Case Reports |
| spelling | doaj-art-98968906043440ceb561b4ffe1f094472025-01-30T16:03:57ZengSAGE PublishingSAGE Open Medical Case Reports2050-313X2025-01-011310.1177/2050313X251316764Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case reportEvangelos Koumasopoulos0Evangelia-Anna Spiteri1Aigli G Vakrakou2Panagiotis Toulas3Georgios Velonakis4George Stranjalis5Leonidas Stefanis6Maria-Eleptheria Evangelopoulos7Maria Anagnostouli8Multiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, GreeceDepartment of Pathology, Evaggelismos Hospital, Athens, GreeceMultiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, GreeceResearch Unit of Radiology, Second Department of Radiology, Aeginition University Hospital, National and Kapodistrian University of Athens, Athens, GreeceResearch Unit of Radiology, Second Department of Radiology, Aeginition University Hospital, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Neurosurgery, National and Kapodistrian University of Athens, Athens, GreeceFirst Department of Neurology. School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, GreeceMultiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, GreeceMultiple Sclerosis and Demyelinating Diseases Unit, Center of Expertise for Rare Demyelinating and Autoimmune Diseases of CNS, First Department of Neurology, School of Medicine, National and Kapodistrian University of Athens, NKUA, Aeginition University Hospital, Athens, GreeceThis is a case presentation of a primary central nervous system B-cell lymphoma in a 69-year-old woman with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids and chronic immunosuppressive treatment. The patient had been diagnosed as having probable chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids, according to international criteria. Afterward, regular clinical and imaging examinations and blood tests were performed. The patient presented with primary central nervous system B-cell lymphoma 3 years after the initial diagnosis of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. Brain tissue histology was indicative of diffuse giant B cells, Epstein–Barr virus positive, and non-Hodgkin lymphoma. The nature of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids is obscure, driving the formulation of many hypotheses about its causes. In our opinion, the presented case supports the putative neoplastic nature of the disease, at least in the long term, and/or along with Epstein–Barr virus involvement, which is known that have been related to other immune-mediated diseases such as multiple sclerosis and malignancies, especially with specific human leukocyte antigen haplotypes. Further research is needed and close monitoring of such patients is strongly recommended.https://doi.org/10.1177/2050313X251316764 |
| spellingShingle | Evangelos Koumasopoulos Evangelia-Anna Spiteri Aigli G Vakrakou Panagiotis Toulas Georgios Velonakis George Stranjalis Leonidas Stefanis Maria-Eleptheria Evangelopoulos Maria Anagnostouli Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report SAGE Open Medical Case Reports |
| title | Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report |
| title_full | Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report |
| title_fullStr | Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report |
| title_full_unstemmed | Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report |
| title_short | Central nervous system B-cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids: A case report |
| title_sort | central nervous system b cell lymphoma in a patient diagnosed with chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids a case report |
| url | https://doi.org/10.1177/2050313X251316764 |
| work_keys_str_mv | AT evangeloskoumasopoulos centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT evangeliaannaspiteri centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT aigligvakrakou centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT panagiotistoulas centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT georgiosvelonakis centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT georgestranjalis centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT leonidasstefanis centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT mariaeleptheriaevangelopoulos centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport AT mariaanagnostouli centralnervoussystembcelllymphomainapatientdiagnosedwithchroniclymphocyticinflammationwithpontineperivascularenhancementresponsivetosteroidsacasereport |