Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans
Gastric cancer is ranked as the most common cancer in Koreans. A recent molecular biological study about the folate pathway gene revealed the correlation with a couple of cancer types. In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltet...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central
2012-09-01
|
| Series: | Genomics & Informatics |
| Subjects: | |
| Online Access: | http://genominfo.org/upload/pdf/gni-10-184.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569542419677184 |
|---|---|
| author | Jae-Young Yoo Sook-Young Kim Jung-Ah Hwang Seung-Hyun Hong Aesun Shin Il Ju Choi Yeon-Su Lee |
| author_facet | Jae-Young Yoo Sook-Young Kim Jung-Ah Hwang Seung-Hyun Hong Aesun Shin Il Ju Choi Yeon-Su Lee |
| author_sort | Jae-Young Yoo |
| collection | DOAJ |
| description | Gastric cancer is ranked as the most common cancer in Koreans. A recent molecular biological study about the folate pathway gene revealed the correlation with a couple of cancer types. In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR). The MTHFR gene has been reported several times for the correlation with gastric cancer risk. However, the association of the MTRR or MTR gene has not been reported to date. In this study, we investigated the association between the single nucleotide polymorphisms (SNPs) of the MTHFR, MTRR, and MTR genes and the risk of gastric cancer in Koreans. To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls. By genotype analysis, estimating odds ratios and 95% confidence intervals (CI), rs1801394 in the MTRR gene showed increased risk for gastric cacner, with statistical significance both in the codominant model (odds ratio [OR], 1.39; 95% CI, 1.04 to 1.85) and dominant model (OR, 1.34; 95% CI, 1.02 to 1.75). Especially, in the obese group (body mass index ≥ 25 kg/m2), the codominant (OR, 9.08; 95% CI, 1.01 to 94.59) and recessive model (OR, 3.72; 95% CI, 0.92 to 16.59) showed dramatically increased risk (p < 0.05). In conclusion, rs1801394 in the MTRR gene is associated with gastric cancer risk, and its functional significance need to be validated. |
| format | Article |
| id | doaj-art-9851f6cddd934db290cccbf9e8d9106d |
| institution | Kabale University |
| issn | 1598-866X 2234-0742 |
| language | English |
| publishDate | 2012-09-01 |
| publisher | BioMed Central |
| record_format | Article |
| series | Genomics & Informatics |
| spelling | doaj-art-9851f6cddd934db290cccbf9e8d9106d2025-02-02T20:46:34ZengBioMed CentralGenomics & Informatics1598-866X2234-07422012-09-0110318419310.5808/GI.2012.10.3.18413Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in KoreansJae-Young Yoo0Sook-Young Kim1Jung-Ah Hwang2Seung-Hyun Hong3Aesun Shin4Il Ju Choi5Yeon-Su Lee6Cancer Genomics Branch, National Cancer Center, Goyang 410-769, Korea.Cancer Genomics Branch, National Cancer Center, Goyang 410-769, Korea.Cancer Genomics Branch, National Cancer Center, Goyang 410-769, Korea.Cancer Genomics Branch, National Cancer Center, Goyang 410-769, Korea.Molecular Epidemiology Branch, National Cancer Center, Goyang 410-769, Korea.Gastric Cancer Branch, Research Institute, National Cancer Center, Goyang 410-769, Korea.Cancer Genomics Branch, National Cancer Center, Goyang 410-769, Korea.Gastric cancer is ranked as the most common cancer in Koreans. A recent molecular biological study about the folate pathway gene revealed the correlation with a couple of cancer types. In the folate pathway, several genes are involved, including methylenetetrahydrofolate reductase (MTHFR), methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR), and methyltetrahydrofolate-homocysteine methyltransferase (MTR). The MTHFR gene has been reported several times for the correlation with gastric cancer risk. However, the association of the MTRR or MTR gene has not been reported to date. In this study, we investigated the association between the single nucleotide polymorphisms (SNPs) of the MTHFR, MTRR, and MTR genes and the risk of gastric cancer in Koreans. To identify the genetic association with gastric cancer, we selected 17 SNPs sites in folate pathway-associated genes of MTHFR, MTR, and MTRR and tested in 1,261 gastric cancer patients and 375 healthy controls. By genotype analysis, estimating odds ratios and 95% confidence intervals (CI), rs1801394 in the MTRR gene showed increased risk for gastric cacner, with statistical significance both in the codominant model (odds ratio [OR], 1.39; 95% CI, 1.04 to 1.85) and dominant model (OR, 1.34; 95% CI, 1.02 to 1.75). Especially, in the obese group (body mass index ≥ 25 kg/m2), the codominant (OR, 9.08; 95% CI, 1.01 to 94.59) and recessive model (OR, 3.72; 95% CI, 0.92 to 16.59) showed dramatically increased risk (p < 0.05). In conclusion, rs1801394 in the MTRR gene is associated with gastric cancer risk, and its functional significance need to be validated.http://genominfo.org/upload/pdf/gni-10-184.pdf5-methyltetrahydrofolate-homocysteine S-methyltransferasefolate pathwaygenetic olymorphismmethionine synthase reductasemethylenetetrahydrofolate reductase (NADPH2)stomach neoplasms |
| spellingShingle | Jae-Young Yoo Sook-Young Kim Jung-Ah Hwang Seung-Hyun Hong Aesun Shin Il Ju Choi Yeon-Su Lee Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans Genomics & Informatics 5-methyltetrahydrofolate-homocysteine S-methyltransferase folate pathway genetic olymorphism methionine synthase reductase methylenetetrahydrofolate reductase (NADPH2) stomach neoplasms |
| title | Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans |
| title_full | Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans |
| title_fullStr | Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans |
| title_full_unstemmed | Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans |
| title_short | Association Study between Folate Pathway Gene Single Nucleotide Polymorphisms and Gastric Cancer in Koreans |
| title_sort | association study between folate pathway gene single nucleotide polymorphisms and gastric cancer in koreans |
| topic | 5-methyltetrahydrofolate-homocysteine S-methyltransferase folate pathway genetic olymorphism methionine synthase reductase methylenetetrahydrofolate reductase (NADPH2) stomach neoplasms |
| url | http://genominfo.org/upload/pdf/gni-10-184.pdf |
| work_keys_str_mv | AT jaeyoungyoo associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT sookyoungkim associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT jungahhwang associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT seunghyunhong associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT aesunshin associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT iljuchoi associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans AT yeonsulee associationstudybetweenfolatepathwaygenesinglenucleotidepolymorphismsandgastriccancerinkoreans |