DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity

DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4+CD25high FOXP3+ Regulatory T Cells but Does Not Affect Their Suppressive Capacity

Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its deriva...

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Bibliographic Details
Main Authors:	Sija Landman, Marjan Cruijsen, Paulo C. M. Urbano, Gerwin Huls, Piet E. J. van Erp, Esther van Rijssen, Irma Joosten, Hans J. P. M. Koenen
Format:	Article
Language:	English
Published:	Wiley 2018-01-01
Series:	Journal of Immunology Research
Online Access:	http://dx.doi.org/10.1155/2018/4973964
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