The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis
ABSTRACT Background and Aim Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We c...
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Wiley
2025-01-01
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| Series: | JGH Open |
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| Online Access: | https://doi.org/10.1002/jgh3.70070 |
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| author | Umar Akram Obaid Ur Rehman Eeshal Fatima Zain Ali Nadeem Omer Usman Waqas Rasheed Ramsha Ali Khawaja Abdul Rehman Abdulqadir J. Nashwan |
| author_facet | Umar Akram Obaid Ur Rehman Eeshal Fatima Zain Ali Nadeem Omer Usman Waqas Rasheed Ramsha Ali Khawaja Abdul Rehman Abdulqadir J. Nashwan |
| author_sort | Umar Akram |
| collection | DOAJ |
| description | ABSTRACT Background and Aim Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We conducted this updated meta‐analysis to assess clinical efficacy of lubiprostone in these patients. Methods A systematic search was conducted on MEDLINE, Cochrane, and Scopus. Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta‐analysis was performed and findings were presented using forest plots. Results A total of 14 studies, comprising 4550 patients, were included in the review. Only 12 studies were pooled in the meta‐analysis. Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). However, it was not associated with abdominal pain in either arm (RR 1.415, 95% CI 0.873–2.294). In opioid‐induced constipation (OIC), lubiprostone increased SBM within 24 h (RR 1.277, 95% CI 1.105–1.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624–29.941). Lubiprostone improved all selected SBM‐related and abdominal pain outcomes in patients with irritable bowel syndrome with constipation (IBS‐C). Conclusion Lubiprostone significantly improves all SBM‐related outcomes. Owing to its good safety and efficacy profile, lubiprostone can be used in the combination regimens for management of CIC, IBS‐C, and OIC. |
| format | Article |
| id | doaj-art-98385cc3fabe416992f09140e10a1dcd |
| institution | Kabale University |
| issn | 2397-9070 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | JGH Open |
| spelling | doaj-art-98385cc3fabe416992f09140e10a1dcd2025-01-28T09:24:32ZengWileyJGH Open2397-90702025-01-0191n/an/a10.1002/jgh3.70070The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐AnalysisUmar Akram0Obaid Ur Rehman1Eeshal Fatima2Zain Ali Nadeem3Omer Usman4Waqas Rasheed5Ramsha Ali6Khawaja Abdul Rehman7Abdulqadir J. Nashwan8Department of Medicine Allama Iqbal Medical College Lahore PakistanDepartment of Medicine Services Institute of Medical Sciences Lahore PakistanDepartment of Medicine Services Institute of Medical Sciences Lahore PakistanDepartment of Medicine Allama Iqbal Medical College Lahore PakistanDepartment of Internal Medicine Texas Tech University Health Sciences Center El Paso/Transmountain Texas USADepartment of Medicine University of Kentucky Lexington Kentucky USADepartment of Medicine People's University of Medical and Health Sciences Nwabshah Shaheed Benazirabad PakistanDepartment of Medicine CMH Lahore Medical College and Institute of Dentistry Lahore PakistanDepartment of Nursing Hamad Medical Corporation Doha QatarABSTRACT Background and Aim Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. Several new clinical trials have emerged since the previous meta‐analysis conducted in 2020. We conducted this updated meta‐analysis to assess clinical efficacy of lubiprostone in these patients. Methods A systematic search was conducted on MEDLINE, Cochrane, and Scopus. Randomized controlled trials published between July 2019 and June 2024 were selected. Cochrane's RoB 2 tool was used to assess the risk of bias. A meta‐analysis was performed and findings were presented using forest plots. Results A total of 14 studies, comprising 4550 patients, were included in the review. Only 12 studies were pooled in the meta‐analysis. Lubiprostone was associated with greater spontaneous bowel movements (SBM) per week (RR 1.454, 95% CI 1.193–1.771) and SBM within 24 h (RR 1.790, 95% CI 1.491–2.150) in patients with chronic idiopathic constipation (CIC). However, it was not associated with abdominal pain in either arm (RR 1.415, 95% CI 0.873–2.294). In opioid‐induced constipation (OIC), lubiprostone increased SBM within 24 h (RR 1.277, 95% CI 1.105–1.475) but did not significantly affect abdominal pain (RR 4.321, 95% CI 0.624–29.941). Lubiprostone improved all selected SBM‐related and abdominal pain outcomes in patients with irritable bowel syndrome with constipation (IBS‐C). Conclusion Lubiprostone significantly improves all SBM‐related outcomes. Owing to its good safety and efficacy profile, lubiprostone can be used in the combination regimens for management of CIC, IBS‐C, and OIC.https://doi.org/10.1002/jgh3.70070chronic idiopathic constipationconstipationirritable bowel syndromelubiprostoneopioid induced constipation |
| spellingShingle | Umar Akram Obaid Ur Rehman Eeshal Fatima Zain Ali Nadeem Omer Usman Waqas Rasheed Ramsha Ali Khawaja Abdul Rehman Abdulqadir J. Nashwan The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis JGH Open chronic idiopathic constipation constipation irritable bowel syndrome lubiprostone opioid induced constipation |
| title | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_full | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_fullStr | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_full_unstemmed | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_short | The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis |
| title_sort | efficacy of lubiprostone in patients of constipation an updated systematic review and meta analysis |
| topic | chronic idiopathic constipation constipation irritable bowel syndrome lubiprostone opioid induced constipation |
| url | https://doi.org/10.1002/jgh3.70070 |
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