Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review
Intravascular large B-cell lymphoma (IVLBCL) is a highly aggressive type of non-Hodgkin’s lymphoma. The clinical manifestations and imaging of this disease are nonspecific, making diagnosis challenging. We report a case of a patient with recurrent stroke-like symptoms, primarily characterized by hem...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1502574/full |
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| author | Jun Li Zhaojiao Li Yifeng Shi Jiajie Chen Heng Zhao Xueye Mao Shan Li Huiying Wang Qiang Meng Lingchun Liu |
| author_facet | Jun Li Zhaojiao Li Yifeng Shi Jiajie Chen Heng Zhao Xueye Mao Shan Li Huiying Wang Qiang Meng Lingchun Liu |
| author_sort | Jun Li |
| collection | DOAJ |
| description | Intravascular large B-cell lymphoma (IVLBCL) is a highly aggressive type of non-Hodgkin’s lymphoma. The clinical manifestations and imaging of this disease are nonspecific, making diagnosis challenging. We report a case of a patient with recurrent stroke-like symptoms, primarily characterized by hemiplegia, vertigo, ataxia, and proteinuria. Brain MRI revealed multiple cerebral infarctions, microbleeds, and meningeal enhancement. Ultimately, the patient was diagnosed with IVLBCL through a brain tissue biopsy, and involvement of the kidneys was suspected. We suggest considering IVLBCL in patients who present with recurrent stroke-like symptoms, fluctuating neurological deficits, the aforementioned MRI findings, and involvement of other organs. Additionally, central nervous system vasculitis(CNSV) may represent a transitional manifestation of the disease. Pathological biopsy is the gold standard for diagnosis. We hope that through this case, doctors can gain a deeper understanding of IVLBCL, enabling early diagnosis and timely treatment to improve prognosis. |
| format | Article |
| id | doaj-art-9825c2b7f39d4d2dbfe4911cf40dc3d5 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-9825c2b7f39d4d2dbfe4911cf40dc3d52025-01-30T06:22:12ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011510.3389/fonc.2025.15025741502574Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature reviewJun Li0Zhaojiao Li1Yifeng Shi2Jiajie Chen3Heng Zhao4Xueye Mao5Shan Li6Huiying Wang7Qiang Meng8Lingchun Liu9Department of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neurosurgery, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neurosurgery, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Neuology, The Affiliated Hospital of Kunming University of Science and Technology, The First People’s Hospital of Yunnan Province, Kunming, ChinaIntravascular large B-cell lymphoma (IVLBCL) is a highly aggressive type of non-Hodgkin’s lymphoma. The clinical manifestations and imaging of this disease are nonspecific, making diagnosis challenging. We report a case of a patient with recurrent stroke-like symptoms, primarily characterized by hemiplegia, vertigo, ataxia, and proteinuria. Brain MRI revealed multiple cerebral infarctions, microbleeds, and meningeal enhancement. Ultimately, the patient was diagnosed with IVLBCL through a brain tissue biopsy, and involvement of the kidneys was suspected. We suggest considering IVLBCL in patients who present with recurrent stroke-like symptoms, fluctuating neurological deficits, the aforementioned MRI findings, and involvement of other organs. Additionally, central nervous system vasculitis(CNSV) may represent a transitional manifestation of the disease. Pathological biopsy is the gold standard for diagnosis. We hope that through this case, doctors can gain a deeper understanding of IVLBCL, enabling early diagnosis and timely treatment to improve prognosis.https://www.frontiersin.org/articles/10.3389/fonc.2025.1502574/fullintravascular large B-cell lymphomacentral nervous system vasculitisMRI imaging featurespathology biopsydifferential diagnosis |
| spellingShingle | Jun Li Zhaojiao Li Yifeng Shi Jiajie Chen Heng Zhao Xueye Mao Shan Li Huiying Wang Qiang Meng Lingchun Liu Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review Frontiers in Oncology intravascular large B-cell lymphoma central nervous system vasculitis MRI imaging features pathology biopsy differential diagnosis |
| title | Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review |
| title_full | Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review |
| title_fullStr | Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review |
| title_full_unstemmed | Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review |
| title_short | Intravascular large B-cell lymphoma of the central nervous system with renal involvement: a case report and literature review |
| title_sort | intravascular large b cell lymphoma of the central nervous system with renal involvement a case report and literature review |
| topic | intravascular large B-cell lymphoma central nervous system vasculitis MRI imaging features pathology biopsy differential diagnosis |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1502574/full |
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