Panic Disorder: Is the PAG Involved?
Data from studies with humans have suggested that abnormalities of midbrain structures, including the periaqueductal gray matter (PAG), could be involved in the neurobiology of panic disorder (PD). The electrical stimulation of the PAG in neurosurgical patients induces panic-like symptoms and the ef...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2009-01-01
|
| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2009/108135 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832551617197506560 |
|---|---|
| author | Cristina Marta Del-Ben Frederico Guilherme Graeff |
| author_facet | Cristina Marta Del-Ben Frederico Guilherme Graeff |
| author_sort | Cristina Marta Del-Ben |
| collection | DOAJ |
| description | Data from studies with humans have suggested that abnormalities of midbrain structures, including the periaqueductal gray matter (PAG), could be involved in the neurobiology of panic disorder (PD). The electrical stimulation of the PAG in neurosurgical patients induces panic-like symptoms and the effect of drugs that are effective in the treatment of PD in the simulation of public speaking model of anxiety is in agreement with data from animal models of PD. Structural neuroimaging studies have shown increases in gray matter volume of midbrain and pons of PD patients. There is also evidence of lower serotonin transporter and receptor binding, and increases of metabolism in the midbrain of PD patients. Nevertheless, these midbrain abnormalities can not be considered as specific findings, since neuroimaging data indicate that PD patients have abnormalities in other brain structures that process fear and anxiety. |
| format | Article |
| id | doaj-art-9823613d4d33488489a56a3b1a4ba892 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-9823613d4d33488489a56a3b1a4ba8922025-02-03T06:01:02ZengWileyNeural Plasticity2090-59041687-54432009-01-01200910.1155/2009/108135108135Panic Disorder: Is the PAG Involved?Cristina Marta Del-Ben0Frederico Guilherme Graeff1Psychiatry Division, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, 14048-900 Ribeirão Preto, SP, BrazilPsychiatry Division, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes, 3900, 14048-900 Ribeirão Preto, SP, BrazilData from studies with humans have suggested that abnormalities of midbrain structures, including the periaqueductal gray matter (PAG), could be involved in the neurobiology of panic disorder (PD). The electrical stimulation of the PAG in neurosurgical patients induces panic-like symptoms and the effect of drugs that are effective in the treatment of PD in the simulation of public speaking model of anxiety is in agreement with data from animal models of PD. Structural neuroimaging studies have shown increases in gray matter volume of midbrain and pons of PD patients. There is also evidence of lower serotonin transporter and receptor binding, and increases of metabolism in the midbrain of PD patients. Nevertheless, these midbrain abnormalities can not be considered as specific findings, since neuroimaging data indicate that PD patients have abnormalities in other brain structures that process fear and anxiety.http://dx.doi.org/10.1155/2009/108135 |
| spellingShingle | Cristina Marta Del-Ben Frederico Guilherme Graeff Panic Disorder: Is the PAG Involved? Neural Plasticity |
| title | Panic Disorder: Is the PAG Involved? |
| title_full | Panic Disorder: Is the PAG Involved? |
| title_fullStr | Panic Disorder: Is the PAG Involved? |
| title_full_unstemmed | Panic Disorder: Is the PAG Involved? |
| title_short | Panic Disorder: Is the PAG Involved? |
| title_sort | panic disorder is the pag involved |
| url | http://dx.doi.org/10.1155/2009/108135 |
| work_keys_str_mv | AT cristinamartadelben panicdisorderisthepaginvolved AT fredericoguilhermegraeff panicdisorderisthepaginvolved |