Botulinum Toxin Suppression of CNS Network Activity In Vitro
The botulinum toxins are potent agents which disrupt synaptic transmission. While the standard method for BoNT detection and quantification is based on the mouse lethality assay, we have examined whether alterations in cultured neuronal network activity can be used to detect the functional effects o...
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Main Authors: | Joseph J. Pancrazio, Kamakshi Gopal, Edward W. Keefer, Guenter W. Gross |
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Format: | Article |
Language: | English |
Published: |
Wiley
2014-01-01
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Series: | Journal of Toxicology |
Online Access: | http://dx.doi.org/10.1155/2014/732913 |
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