The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent
Radiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2018/4786819 |
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| _version_ | 1832568014291075072 |
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| author | Jessica M. S. Jutzy Jeffrey M. Lemons Jason J. Luke Steven J. Chmura |
| author_facet | Jessica M. S. Jutzy Jeffrey M. Lemons Jason J. Luke Steven J. Chmura |
| author_sort | Jessica M. S. Jutzy |
| collection | DOAJ |
| description | Radiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic setting is evolving to harness its immune-enhancing properties. Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. The use of immunotherapeutics to promote antitumoral immunity has resulted in improved treatment responses in patients with metastatic disease and the combination of radiation therapy and immunotherapy has become an area of intense investigation. In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy. |
| format | Article |
| id | doaj-art-9815217de6c94172b438b1275eb9c669 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-9815217de6c94172b438b1275eb9c6692025-02-03T00:59:56ZengWileyInternational Journal of Breast Cancer2090-31702090-31892018-01-01201810.1155/2018/47868194786819The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic AgentJessica M. S. Jutzy0Jeffrey M. Lemons1Jason J. Luke2Steven J. Chmura3Department of Radiation Oncology, University of Chicago, Chicago, IL, USADepartment of Radiation Oncology, University of Chicago, Chicago, IL, USADepartment of Medicine, University of Chicago, Chicago, IL, USADepartment of Radiation Oncology, University of Chicago, Chicago, IL, USARadiation therapy is a mainstay of treatment in early and locally advanced breast cancer but is typically reserved for palliation of symptomatic lesions in patients with metastatic breast cancer. With new advances in the field of tumor biology and immunology, the role of radiation in the metastatic setting is evolving to harness its immune-enhancing properties. Through the release of tumor antigens, tumor DNA, and cytokines into the tumor microenvironment, radiation augments the antitumoral immune response to affect both the targeted lesion and distant sites of metastatic disease. The use of immunotherapeutics to promote antitumoral immunity has resulted in improved treatment responses in patients with metastatic disease and the combination of radiation therapy and immunotherapy has become an area of intense investigation. In this article, we will review the emerging role of radiation in the treatment of metastatic disease and discuss the current state of the science and clinical trials investigating the combination of radiation and immunotherapy.http://dx.doi.org/10.1155/2018/4786819 |
| spellingShingle | Jessica M. S. Jutzy Jeffrey M. Lemons Jason J. Luke Steven J. Chmura The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent International Journal of Breast Cancer |
| title | The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent |
| title_full | The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent |
| title_fullStr | The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent |
| title_full_unstemmed | The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent |
| title_short | The Evolution of Radiation Therapy in Metastatic Breast Cancer: From Local Therapy to Systemic Agent |
| title_sort | evolution of radiation therapy in metastatic breast cancer from local therapy to systemic agent |
| url | http://dx.doi.org/10.1155/2018/4786819 |
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