A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year
BackgroundStroke recurrence is a serious and prevalent complication of ischemic stroke that warrants additional investigation.MethodsA hospital-based retrospective observational study included acute-subacute ischemic stroke adult patients. The primary aim was to determine the risk factors associated...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1478175/full |
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| author | Eman A. Alraddadi Eman A. Alraddadi Hashim F. Alotaibi Hashim F. Alotaibi Yasser Alatawi Ahmed Aljabri Ahmed A. Alghamdi Ahmed A. Alghamdi Fahad Alturki Fahad Alturki Faisal F. Alamri Faisal F. Alamri |
| author_facet | Eman A. Alraddadi Eman A. Alraddadi Hashim F. Alotaibi Hashim F. Alotaibi Yasser Alatawi Ahmed Aljabri Ahmed A. Alghamdi Ahmed A. Alghamdi Fahad Alturki Fahad Alturki Faisal F. Alamri Faisal F. Alamri |
| author_sort | Eman A. Alraddadi |
| collection | DOAJ |
| description | BackgroundStroke recurrence is a serious and prevalent complication of ischemic stroke that warrants additional investigation.MethodsA hospital-based retrospective observational study included acute-subacute ischemic stroke adult patients. The primary aim was to determine the risk factors associated with recurrent stroke within 365 days. Additionally, a combined outcome consisting of any stroke recurrence or all-cause mortality within 365 days was considered secondary outcome. Univariate and multivariable Cox proportional-hazards models were used to examine the association of risk factors with stroke recurrence and composite death/stroke recurrence.ResultsOf 1,244 patients, 112 (9%) experienced stroke recurrence. The multivariable analysis identified risk factors for stroke recurrence including history of previous stroke (HR = 3.65, 95% CI:2.28–5.99, p = 0.0001), tissue plasminogen activator (tPA) treatment (HR = 2.84, 95% CI:1.57–4.86, p = 0.0003), seizure (HR = 1.96, 95% CI:1.14–3.22, p = 0.0105), and depression (HR = 2.26, 95% CI:1.33–3.69, p = 0.0016). Only previous stroke history (HR = 2.37, 95% CI:1.74–3.26, p = 0.0001) remained significantly associated with the combined outcome of stroke recurrence/death. Additional risk factors for the composite outcome included older age of patients (HR = 1.02, 95% CI:1.01–1.03, p = 0.0009), admission to the intensive care unit (ICU) (HR = 3.70, 95% CI:2.63–5.22, p = 0.0105), pneumonia (HR = 1.47, 95% CI:1.05–2.05, p = 0.0249), and brain edema (HR = 2.36, 95% CI:1.58–3.46, p = 0.0001).ConclusionKey findings include a stroke recurrence rate of 9.96% and a combined death/stroke recurrence rate of 21.83% within 365 days. Multivariable analysis confirmed that history of stroke, receiving tPA, experiencing seizures, and depression were significantly associated with stroke recurrence. Implementing additional preventive measures for individuals in these high-risk categories is essential. Further studies are needed to validate our findings. |
| format | Article |
| id | doaj-art-9813793b73b743c3ac32bf7147aad6ec |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-9813793b73b743c3ac32bf7147aad6ec2025-02-05T05:17:46ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-02-011610.3389/fneur.2025.14781751478175A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 yearEman A. Alraddadi0Eman A. Alraddadi1Hashim F. Alotaibi2Hashim F. Alotaibi3Yasser Alatawi4Ahmed Aljabri5Ahmed A. Alghamdi6Ahmed A. Alghamdi7Fahad Alturki8Fahad Alturki9Faisal F. Alamri10Faisal F. Alamri11Department of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaDepartment of Pharmacy Practice, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi ArabiaDepartment of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi ArabiaDepartment of Basic Sciences, College of Science and Health Professions, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi ArabiaKing Abdullah International Medical Research Center, Jeddah, Saudi ArabiaBackgroundStroke recurrence is a serious and prevalent complication of ischemic stroke that warrants additional investigation.MethodsA hospital-based retrospective observational study included acute-subacute ischemic stroke adult patients. The primary aim was to determine the risk factors associated with recurrent stroke within 365 days. Additionally, a combined outcome consisting of any stroke recurrence or all-cause mortality within 365 days was considered secondary outcome. Univariate and multivariable Cox proportional-hazards models were used to examine the association of risk factors with stroke recurrence and composite death/stroke recurrence.ResultsOf 1,244 patients, 112 (9%) experienced stroke recurrence. The multivariable analysis identified risk factors for stroke recurrence including history of previous stroke (HR = 3.65, 95% CI:2.28–5.99, p = 0.0001), tissue plasminogen activator (tPA) treatment (HR = 2.84, 95% CI:1.57–4.86, p = 0.0003), seizure (HR = 1.96, 95% CI:1.14–3.22, p = 0.0105), and depression (HR = 2.26, 95% CI:1.33–3.69, p = 0.0016). Only previous stroke history (HR = 2.37, 95% CI:1.74–3.26, p = 0.0001) remained significantly associated with the combined outcome of stroke recurrence/death. Additional risk factors for the composite outcome included older age of patients (HR = 1.02, 95% CI:1.01–1.03, p = 0.0009), admission to the intensive care unit (ICU) (HR = 3.70, 95% CI:2.63–5.22, p = 0.0105), pneumonia (HR = 1.47, 95% CI:1.05–2.05, p = 0.0249), and brain edema (HR = 2.36, 95% CI:1.58–3.46, p = 0.0001).ConclusionKey findings include a stroke recurrence rate of 9.96% and a combined death/stroke recurrence rate of 21.83% within 365 days. Multivariable analysis confirmed that history of stroke, receiving tPA, experiencing seizures, and depression were significantly associated with stroke recurrence. Implementing additional preventive measures for individuals in these high-risk categories is essential. Further studies are needed to validate our findings.https://www.frontiersin.org/articles/10.3389/fneur.2025.1478175/fullstroke recurrencemortalityischemic strokerisk factorsstroke complication |
| spellingShingle | Eman A. Alraddadi Eman A. Alraddadi Hashim F. Alotaibi Hashim F. Alotaibi Yasser Alatawi Ahmed Aljabri Ahmed A. Alghamdi Ahmed A. Alghamdi Fahad Alturki Fahad Alturki Faisal F. Alamri Faisal F. Alamri A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year Frontiers in Neurology stroke recurrence mortality ischemic stroke risk factors stroke complication |
| title | A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| title_full | A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| title_fullStr | A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| title_full_unstemmed | A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| title_short | A multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| title_sort | multicenter analysis to identify the risk factors for stroke recurrence and mortality within 1 year |
| topic | stroke recurrence mortality ischemic stroke risk factors stroke complication |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1478175/full |
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