Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis
Background. Terminalia arjuna is a popular Indian medicinal plant with its bark been used for over centuries as cardiotonic. The bark has been found to contain several bioactive compounds including saponins and flavonoids. A number of experimental and clinical studies have been conducted to explore...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/281483 |
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| author | Navjot Kaur Nusrat Shafiq Harish Negi Avaneesh Pandey Srinivas Reddy Harpreet Kaur Neelima Chadha Samir Malhotra |
| author_facet | Navjot Kaur Nusrat Shafiq Harish Negi Avaneesh Pandey Srinivas Reddy Harpreet Kaur Neelima Chadha Samir Malhotra |
| author_sort | Navjot Kaur |
| collection | DOAJ |
| description | Background. Terminalia arjuna is a popular Indian medicinal plant with its bark been used for over centuries as cardiotonic. The bark has been found to contain several bioactive compounds including saponins and flavonoids. A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. A number of narrative reviews have been done but no systematic review has been conducted to date. Objective. To systematically review and conduct a meta-analysis on the available literature evaluating the efficacy of Terminalia arjuna in patients of chronic stable angina. Study selection. We included randomised, pseudo-randomized and before-after comparative studies which compared Terminalia arjuna/commercial preparation of Terminalia arjuna with current standard/ conventional treatment regimens in patients with chronic stable angina. Findings. Studies were found to be of poor methodological design. We found no significant difference in the Terminalia arjuna group as compared to control arm in the outcomes for which we were able to pool data and undertake meta-analysis. Conclusions. Currently, the evidence is insufficient to draw any definite conclusions in favour of or against Terminalia arjuna in patients of chronic stable angina. Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any. |
| format | Article |
| id | doaj-art-97f02ab1b69044d493b8cccae276e3a2 |
| institution | Kabale University |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-97f02ab1b69044d493b8cccae276e3a22025-02-03T01:02:00ZengWileyCardiology Research and Practice2090-80162090-05972014-01-01201410.1155/2014/281483281483Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-AnalysisNavjot Kaur0Nusrat Shafiq1Harish Negi2Avaneesh Pandey3Srinivas Reddy4Harpreet Kaur5Neelima Chadha6Samir Malhotra7Department of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Cardiology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaICMR Advanced Centre for Evidence-Based Child Health, Advanced Paediatrics Centre, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDr. Tulsidas Library, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaDepartment of Pharmacology, Postgraduate Institute of Medical Education & Research, Chandigarh 160012, IndiaBackground. Terminalia arjuna is a popular Indian medicinal plant with its bark been used for over centuries as cardiotonic. The bark has been found to contain several bioactive compounds including saponins and flavonoids. A number of experimental and clinical studies have been conducted to explore therapeutic potential of Terminalia arjuna in cardiovascular ailments specially in patients of coronary heart disease. A number of narrative reviews have been done but no systematic review has been conducted to date. Objective. To systematically review and conduct a meta-analysis on the available literature evaluating the efficacy of Terminalia arjuna in patients of chronic stable angina. Study selection. We included randomised, pseudo-randomized and before-after comparative studies which compared Terminalia arjuna/commercial preparation of Terminalia arjuna with current standard/ conventional treatment regimens in patients with chronic stable angina. Findings. Studies were found to be of poor methodological design. We found no significant difference in the Terminalia arjuna group as compared to control arm in the outcomes for which we were able to pool data and undertake meta-analysis. Conclusions. Currently, the evidence is insufficient to draw any definite conclusions in favour of or against Terminalia arjuna in patients of chronic stable angina. Further, well-controlled multicentric clinical trials need to be conducted in large number of patients to explore the therapeutic potential of Terminalia arjuna if any.http://dx.doi.org/10.1155/2014/281483 |
| spellingShingle | Navjot Kaur Nusrat Shafiq Harish Negi Avaneesh Pandey Srinivas Reddy Harpreet Kaur Neelima Chadha Samir Malhotra Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis Cardiology Research and Practice |
| title | Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis |
| title_full | Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis |
| title_fullStr | Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis |
| title_full_unstemmed | Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis |
| title_short | Terminalia arjuna in Chronic Stable Angina: Systematic Review and Meta-Analysis |
| title_sort | terminalia arjuna in chronic stable angina systematic review and meta analysis |
| url | http://dx.doi.org/10.1155/2014/281483 |
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