Association between ethylene oxide exposure and cognitive function in older adults from NHANES data
Abstract Ethylene Oxide (EO), a volatile organic compound, has garnered considerable attention for its potential impact on human health. Yet, the ramifications of EO exposure on the cognitive functionality of the elderly remain unclear. The aim of this study is to determine whether EO exposure in th...
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Nature Portfolio
2025-01-01
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| author | Meng Sun Meng Cai Sisi Sun Huan Liu Guo Chen |
| author_facet | Meng Sun Meng Cai Sisi Sun Huan Liu Guo Chen |
| author_sort | Meng Sun |
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| description | Abstract Ethylene Oxide (EO), a volatile organic compound, has garnered considerable attention for its potential impact on human health. Yet, the ramifications of EO exposure on the cognitive functionality of the elderly remain unclear. The aim of this study is to determine whether EO exposure in the elderly correlates with cognitive function. In this cross-sectional study, an analysis was conducted on 471 participants from the 2013 to 2014 United States National Health and Nutrition Examination Survey (NHANES). T1, T2, and T3 was used to represent the low, moderate, and high tertiles of log10-transformed HbEO levels, respectively. Weighted linear regression analysis, weighted logistic regression analysis, and restricted cubic spline models were employed to assess the association between HbEO and standardized z-scores of four cognitive tests. Firstly, analysis of variable characteristics across the different log10-transformed HbEO groups revealed that HbEO was higher in males, non-Hispanic whites, and smokers and that Z scores for Delayed Recall Test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST) decreased as HbEO increased (p < 0.05). After adjusting for confounding factors, the log10-transformed HbEO levels were found to be negatively correlated with DRT-Z scores (T3 vs. T1 in Model 3: β (95% CI) = − 0.35 (− 0.54, − 0.15), p = 0.002, p for trend = 0.002). In addition, Stratified analyses showed that the four cognitive scores were negatively correlated with HbEO levels in those under 80 years of age. And men had worse AFT scores compared to women. Overall, the four Z-scores roughly trended downward as log10-transformed HbEO rose. Based on the findings of this research, EO exposure may be associated with adverse performance in the DRT among elderly individuals in the United States. |
| format | Article |
| id | doaj-art-97ea6015da7b4021b28c4e25e5d431fa |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-97ea6015da7b4021b28c4e25e5d431fa2025-02-02T12:20:11ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87384-yAssociation between ethylene oxide exposure and cognitive function in older adults from NHANES dataMeng Sun0Meng Cai1Sisi Sun2Huan Liu3Guo Chen4Department of Anesthesiology, West China Hospital, Sichuan UniversityNanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityNanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing UniversityDepartment of Anesthesiology, Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Anesthesiology, West China Hospital, Sichuan UniversityAbstract Ethylene Oxide (EO), a volatile organic compound, has garnered considerable attention for its potential impact on human health. Yet, the ramifications of EO exposure on the cognitive functionality of the elderly remain unclear. The aim of this study is to determine whether EO exposure in the elderly correlates with cognitive function. In this cross-sectional study, an analysis was conducted on 471 participants from the 2013 to 2014 United States National Health and Nutrition Examination Survey (NHANES). T1, T2, and T3 was used to represent the low, moderate, and high tertiles of log10-transformed HbEO levels, respectively. Weighted linear regression analysis, weighted logistic regression analysis, and restricted cubic spline models were employed to assess the association between HbEO and standardized z-scores of four cognitive tests. Firstly, analysis of variable characteristics across the different log10-transformed HbEO groups revealed that HbEO was higher in males, non-Hispanic whites, and smokers and that Z scores for Delayed Recall Test (DRT), Animal Fluency Test (AFT), and Digit Symbol Substitution Test (DSST) decreased as HbEO increased (p < 0.05). After adjusting for confounding factors, the log10-transformed HbEO levels were found to be negatively correlated with DRT-Z scores (T3 vs. T1 in Model 3: β (95% CI) = − 0.35 (− 0.54, − 0.15), p = 0.002, p for trend = 0.002). In addition, Stratified analyses showed that the four cognitive scores were negatively correlated with HbEO levels in those under 80 years of age. And men had worse AFT scores compared to women. Overall, the four Z-scores roughly trended downward as log10-transformed HbEO rose. Based on the findings of this research, EO exposure may be associated with adverse performance in the DRT among elderly individuals in the United States.https://doi.org/10.1038/s41598-025-87384-yEthylene oxideNHANESCognitive functionCross-sectional studyEpidemiology |
| spellingShingle | Meng Sun Meng Cai Sisi Sun Huan Liu Guo Chen Association between ethylene oxide exposure and cognitive function in older adults from NHANES data Scientific Reports Ethylene oxide NHANES Cognitive function Cross-sectional study Epidemiology |
| title | Association between ethylene oxide exposure and cognitive function in older adults from NHANES data |
| title_full | Association between ethylene oxide exposure and cognitive function in older adults from NHANES data |
| title_fullStr | Association between ethylene oxide exposure and cognitive function in older adults from NHANES data |
| title_full_unstemmed | Association between ethylene oxide exposure and cognitive function in older adults from NHANES data |
| title_short | Association between ethylene oxide exposure and cognitive function in older adults from NHANES data |
| title_sort | association between ethylene oxide exposure and cognitive function in older adults from nhanes data |
| topic | Ethylene oxide NHANES Cognitive function Cross-sectional study Epidemiology |
| url | https://doi.org/10.1038/s41598-025-87384-y |
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