The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report
Purpose. To explore the burden of prostate biopsy at the time of its indication, procedure, and pathological report in the prostate cancer-screening scenario that is neglected and underestimated in the literature. Methods. Prostate biopsy was offered to 47 consecutive patients with prostate-specific...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2019/2653708 |
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| author | Walker W. Laranja Brunno C. F. Sanches Brunno R. I. Voris João C. C. Alonso Fabiano A. Simões Ronald F. Rejowski Leonardo O. Reis |
| author_facet | Walker W. Laranja Brunno C. F. Sanches Brunno R. I. Voris João C. C. Alonso Fabiano A. Simões Ronald F. Rejowski Leonardo O. Reis |
| author_sort | Walker W. Laranja |
| collection | DOAJ |
| description | Purpose. To explore the burden of prostate biopsy at the time of its indication, procedure, and pathological report in the prostate cancer-screening scenario that is neglected and underestimated in the literature. Methods. Prostate biopsy was offered to 47 consecutive patients with prostate-specific antigen (PSA) over 4 ng/dl or suspicious digital rectal examination (DRE) of whom 16 had undergone a biopsy. Comprehensive validated questionnaires at Time 0 (prebiopsy), Time 1 (before diagnosis, 20 days after biopsy), and Time 2 (after diagnosis, 40 days after biopsy) accessed patients' erectile (IIEF-5) and voiding (IPSS) functions, Beck scales measured anxiety (BAI), hopelessness (BHS), and depression (BDI), added to the emotional thermometers including five visual analog scales for distress, anxiety, depression, anger, and need for help. The Mann-Whitney or Friedman tests were obtained among times and studied variables. Results. Prostate biopsy did not significantly impact patients' erectile and voiding functions while a higher Beck anxiety index (BAI) was observed at Time 0 (6.89 ± 6.33) compared to Time 1 (4.83 ± 2.87), p=0.0214, and to Time 2 (4.22 ± 4.98), p=0.0178. At Time 0, patients that experienced a previous biopsy presented higher distress (3.1 ± 3.0 vs. 1.6 ± 2.3), p=0.043, and emotional suffering thermometer scores (2.3 ± 3.3 vs. 0.9 ± 2.4) compared to those undergoing the first biopsy, p=0.036. At Time 2, patients with positive biopsies compared with those with negative ones showed no significant difference in outcome scores. The sample power was >90%. Conclusions. To be considered in patients' counseling and care, the current study supports the hypothesis that the peak burden of prostate biopsy occurs at the time of its indication and might be higher for those experiencing rebiopsy, significantly impacting patients' psychosocial domains. Trial Approval. This trial is registered under number NCT03783741. |
| format | Article |
| id | doaj-art-97e51c7cea144630b8379894007fbf2b |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-97e51c7cea144630b8379894007fbf2b2025-02-03T06:00:10ZengWileyProstate Cancer2090-31112090-312X2019-01-01201910.1155/2019/26537082653708The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological ReportWalker W. Laranja0Brunno C. F. Sanches1Brunno R. I. Voris2João C. C. Alonso3Fabiano A. Simões4Ronald F. Rejowski5Leonardo O. Reis6University of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilUniversity of Campinas (Unicamp), Campinas, São Paulo, BrazilPurpose. To explore the burden of prostate biopsy at the time of its indication, procedure, and pathological report in the prostate cancer-screening scenario that is neglected and underestimated in the literature. Methods. Prostate biopsy was offered to 47 consecutive patients with prostate-specific antigen (PSA) over 4 ng/dl or suspicious digital rectal examination (DRE) of whom 16 had undergone a biopsy. Comprehensive validated questionnaires at Time 0 (prebiopsy), Time 1 (before diagnosis, 20 days after biopsy), and Time 2 (after diagnosis, 40 days after biopsy) accessed patients' erectile (IIEF-5) and voiding (IPSS) functions, Beck scales measured anxiety (BAI), hopelessness (BHS), and depression (BDI), added to the emotional thermometers including five visual analog scales for distress, anxiety, depression, anger, and need for help. The Mann-Whitney or Friedman tests were obtained among times and studied variables. Results. Prostate biopsy did not significantly impact patients' erectile and voiding functions while a higher Beck anxiety index (BAI) was observed at Time 0 (6.89 ± 6.33) compared to Time 1 (4.83 ± 2.87), p=0.0214, and to Time 2 (4.22 ± 4.98), p=0.0178. At Time 0, patients that experienced a previous biopsy presented higher distress (3.1 ± 3.0 vs. 1.6 ± 2.3), p=0.043, and emotional suffering thermometer scores (2.3 ± 3.3 vs. 0.9 ± 2.4) compared to those undergoing the first biopsy, p=0.036. At Time 2, patients with positive biopsies compared with those with negative ones showed no significant difference in outcome scores. The sample power was >90%. Conclusions. To be considered in patients' counseling and care, the current study supports the hypothesis that the peak burden of prostate biopsy occurs at the time of its indication and might be higher for those experiencing rebiopsy, significantly impacting patients' psychosocial domains. Trial Approval. This trial is registered under number NCT03783741.http://dx.doi.org/10.1155/2019/2653708 |
| spellingShingle | Walker W. Laranja Brunno C. F. Sanches Brunno R. I. Voris João C. C. Alonso Fabiano A. Simões Ronald F. Rejowski Leonardo O. Reis The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report Prostate Cancer |
| title | The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report |
| title_full | The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report |
| title_fullStr | The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report |
| title_full_unstemmed | The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report |
| title_short | The Biopsychosocial Burden of Prostate Biopsy at the Time of Its Indication, Procedure, and Pathological Report |
| title_sort | biopsychosocial burden of prostate biopsy at the time of its indication procedure and pathological report |
| url | http://dx.doi.org/10.1155/2019/2653708 |
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