Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i>
Mutations in highly conserved genes encoding components of the electron transport chain (ETC) provide valuable insights into the mechanisms of oxidative stress and mitochondrial ROS (mtROS) in a wide range of diseases, including cancer, neurodegenerative disorders, and aging. This review explores th...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/14/1/76 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589276713320448 |
|---|---|
| author | Fanni Ősz Aamir Nazir Krisztina Takács-Vellai Zsolt Farkas |
| author_facet | Fanni Ősz Aamir Nazir Krisztina Takács-Vellai Zsolt Farkas |
| author_sort | Fanni Ősz |
| collection | DOAJ |
| description | Mutations in highly conserved genes encoding components of the electron transport chain (ETC) provide valuable insights into the mechanisms of oxidative stress and mitochondrial ROS (mtROS) in a wide range of diseases, including cancer, neurodegenerative disorders, and aging. This review explores the structure and function of the ETC in the context of its role in mtROS generation and regulation, emphasizing its dual roles in cellular damage and signaling. Using <i>Caenorhabditis elegans</i> as a model organism, we discuss how ETC mutations manifest as developmental abnormalities, lifespan alterations, and changes in mtROS levels. We highlight the utility of redox sensors in <i>C. elegans</i> for in vivo studies of reactive oxygen species, offering both quantitative and qualitative insights. Finally, we examine the potential of <i>C. elegans</i> as a platform for testing ETC-targeting drug candidates, including OXPHOS inhibitors, which represent promising avenues in cancer therapeutics. This review underscores the translational relevance of ETC research in <i>C. elegans</i>, bridging fundamental biology and therapeutic innovation. |
| format | Article |
| id | doaj-art-97d9fbe5c5e544cc8da9f857c28d1081 |
| institution | Kabale University |
| issn | 2076-3921 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj-art-97d9fbe5c5e544cc8da9f857c28d10812025-01-24T13:19:24ZengMDPI AGAntioxidants2076-39212025-01-011417610.3390/antiox14010076Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i>Fanni Ősz0Aamir Nazir1Krisztina Takács-Vellai2Zsolt Farkas3Department of Biological Anthropology, Eötvös Loránd University, Pázmány P. stny. 1/C, H-1117 Budapest, HungaryLaboratory of Functional Genomics and Molecular Toxicology, Division of Toxicology, CSIR-Central Drug Research Institute, Lucknow 226031, IndiaDepartment of Biological Anthropology, Eötvös Loránd University, Pázmány P. stny. 1/C, H-1117 Budapest, HungaryDepartment of Biological Anthropology, Eötvös Loránd University, Pázmány P. stny. 1/C, H-1117 Budapest, HungaryMutations in highly conserved genes encoding components of the electron transport chain (ETC) provide valuable insights into the mechanisms of oxidative stress and mitochondrial ROS (mtROS) in a wide range of diseases, including cancer, neurodegenerative disorders, and aging. This review explores the structure and function of the ETC in the context of its role in mtROS generation and regulation, emphasizing its dual roles in cellular damage and signaling. Using <i>Caenorhabditis elegans</i> as a model organism, we discuss how ETC mutations manifest as developmental abnormalities, lifespan alterations, and changes in mtROS levels. We highlight the utility of redox sensors in <i>C. elegans</i> for in vivo studies of reactive oxygen species, offering both quantitative and qualitative insights. Finally, we examine the potential of <i>C. elegans</i> as a platform for testing ETC-targeting drug candidates, including OXPHOS inhibitors, which represent promising avenues in cancer therapeutics. This review underscores the translational relevance of ETC research in <i>C. elegans</i>, bridging fundamental biology and therapeutic innovation.https://www.mdpi.com/2076-3921/14/1/76ETCelectron transport chainSDHsuccinate dehydrogenaseROSreactive oxygen species |
| spellingShingle | Fanni Ősz Aamir Nazir Krisztina Takács-Vellai Zsolt Farkas Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> Antioxidants ETC electron transport chain SDH succinate dehydrogenase ROS reactive oxygen species |
| title | Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> |
| title_full | Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> |
| title_fullStr | Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> |
| title_full_unstemmed | Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> |
| title_short | Mutations of the Electron Transport Chain Affect Lifespan and ROS Levels in <i>C. elegans</i> |
| title_sort | mutations of the electron transport chain affect lifespan and ros levels in i c elegans i |
| topic | ETC electron transport chain SDH succinate dehydrogenase ROS reactive oxygen species |
| url | https://www.mdpi.com/2076-3921/14/1/76 |
| work_keys_str_mv | AT fanniosz mutationsoftheelectrontransportchainaffectlifespanandroslevelsinicelegansi AT aamirnazir mutationsoftheelectrontransportchainaffectlifespanandroslevelsinicelegansi AT krisztinatakacsvellai mutationsoftheelectrontransportchainaffectlifespanandroslevelsinicelegansi AT zsoltfarkas mutationsoftheelectrontransportchainaffectlifespanandroslevelsinicelegansi |