Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group
Purpose. To assess the risk for capsular rupture during routine phacoemulsification in patients with a history of anti-VEGF injections and other possible risk modifiers such as treatment patterns, type of anti-VEGF agent, and experience of the surgeon, among others. Methods. This study reviewed the...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2021/5591865 |
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| author | Raul Velez-Montoya Idaira Sanchez-Santos Mauricio Galvan-Chavez Lihteh Wu J. Fernando Arevalo María H. Berrocal Arturo A. Alezzandrini Marta S. Figueroa Roberto Gallego-Pinazo Rosa Dolz-Marco Clara Martinez-Rubio Roberto Gonzalez-Salinas |
| author_facet | Raul Velez-Montoya Idaira Sanchez-Santos Mauricio Galvan-Chavez Lihteh Wu J. Fernando Arevalo María H. Berrocal Arturo A. Alezzandrini Marta S. Figueroa Roberto Gallego-Pinazo Rosa Dolz-Marco Clara Martinez-Rubio Roberto Gonzalez-Salinas |
| author_sort | Raul Velez-Montoya |
| collection | DOAJ |
| description | Purpose. To assess the risk for capsular rupture during routine phacoemulsification in patients with a history of anti-VEGF injections and other possible risk modifiers such as treatment patterns, type of anti-VEGF agent, and experience of the surgeon, among others. Methods. This study reviewed the medical records of 11,129 patients from 7 different hospitals in 5 countries. The study included 939 patients that underwent routine phacoemulsification and had a history of anti-VEGF therapy. We excluded patients with known risk factors for capsular rupture, as well as patients with a history of other retinal procedures. The study extracted data regarding general demographics, the number of previous injections, type of anti-VEGF agent, details of cataract surgery, and anti-VEGF treatment patterns. Results. Overall prevalence of posterior capsular rupture: 7.45% (95% CI: 5.9–9.32%). The mean number of injections per patient was 3.37 ± 2.8. More than 50% of the patients received their last anti-VEGF injection within three months before cataract surgery. The complication rate during intravitreal injections was 1.07%. In the univariate analysis, the experience of the cataract surgeon (inexperience surgeons; OR: 2.93) and the history of prior anti-VEGF therapy (OR: 1.77) were significant risk indicators for PCR (p<0.05). However, after controlling for age in the multivariate analysis, the trend did not reach a statistical significance. Conclusion. The risk for capsular rupture is higher in patients with a history of intravitreal anti-VEGF injections. |
| format | Article |
| id | doaj-art-97d2939f65d84e839e3fe9f80e2da458 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-97d2939f65d84e839e3fe9f80e2da4582025-02-03T01:27:05ZengWileyJournal of Ophthalmology2090-004X2090-00582021-01-01202110.1155/2021/55918655591865Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) GroupRaul Velez-Montoya0Idaira Sanchez-Santos1Mauricio Galvan-Chavez2Lihteh Wu3J. Fernando Arevalo4María H. Berrocal5Arturo A. Alezzandrini6Marta S. Figueroa7Roberto Gallego-Pinazo8Rosa Dolz-Marco9Clara Martinez-Rubio10Roberto Gonzalez-Salinas11Retina Department, Asociación para Evitar le Ceguera en México IAP, México City 04030, MexicoRetina Department, Asociación para Evitar le Ceguera en México IAP, México City 04030, MexicoRetina Department, Asociación para Evitar le Ceguera en México IAP, México City 04030, MexicoAsociados de Macula, Vitreo y Retina de Costa Rica, San Jose City 10102, Costa RicaRetina Division, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USADepartment of Ophthalmology, University of Puerto Rico, San Juan, PR 00907, USAOphthalmology Department, University of Buenos Aires, School of Medicine, Buenos Aires C1121, ArgentinaRetina and Vitreous Department, Hospital Universitario Ramón y Cajal, Madrid 28034, SpainOphthalmology Department, Hospital Universitario y Politécnico La Fe, Valencia 46026, SpainOphthalmology Department, Hospital Universitario y Politécnico La Fe, Valencia 46026, SpainOphthalmology Department, Hospital Universitario y Politécnico La Fe, Valencia 46026, SpainAnterior Segment Department, Asociación para Evitar le Ceguera en México IAP, DF 04030, México City, MexicoPurpose. To assess the risk for capsular rupture during routine phacoemulsification in patients with a history of anti-VEGF injections and other possible risk modifiers such as treatment patterns, type of anti-VEGF agent, and experience of the surgeon, among others. Methods. This study reviewed the medical records of 11,129 patients from 7 different hospitals in 5 countries. The study included 939 patients that underwent routine phacoemulsification and had a history of anti-VEGF therapy. We excluded patients with known risk factors for capsular rupture, as well as patients with a history of other retinal procedures. The study extracted data regarding general demographics, the number of previous injections, type of anti-VEGF agent, details of cataract surgery, and anti-VEGF treatment patterns. Results. Overall prevalence of posterior capsular rupture: 7.45% (95% CI: 5.9–9.32%). The mean number of injections per patient was 3.37 ± 2.8. More than 50% of the patients received their last anti-VEGF injection within three months before cataract surgery. The complication rate during intravitreal injections was 1.07%. In the univariate analysis, the experience of the cataract surgeon (inexperience surgeons; OR: 2.93) and the history of prior anti-VEGF therapy (OR: 1.77) were significant risk indicators for PCR (p<0.05). However, after controlling for age in the multivariate analysis, the trend did not reach a statistical significance. Conclusion. The risk for capsular rupture is higher in patients with a history of intravitreal anti-VEGF injections.http://dx.doi.org/10.1155/2021/5591865 |
| spellingShingle | Raul Velez-Montoya Idaira Sanchez-Santos Mauricio Galvan-Chavez Lihteh Wu J. Fernando Arevalo María H. Berrocal Arturo A. Alezzandrini Marta S. Figueroa Roberto Gallego-Pinazo Rosa Dolz-Marco Clara Martinez-Rubio Roberto Gonzalez-Salinas Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group Journal of Ophthalmology |
| title | Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group |
| title_full | Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group |
| title_fullStr | Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group |
| title_full_unstemmed | Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group |
| title_short | Risk of Posterior Capsular Rupture during Phacoemulsification in Patients with the History of Anti-VEGF Intravitreal Injections: Results from the Pan-American Collaborative Retina Study (PACORES) Group |
| title_sort | risk of posterior capsular rupture during phacoemulsification in patients with the history of anti vegf intravitreal injections results from the pan american collaborative retina study pacores group |
| url | http://dx.doi.org/10.1155/2021/5591865 |
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