A case report and literature review of livedoid vasculopathy in children
BackgroundLivedoid vasculopathy (LV) is a rare, non-inflammatory, intradermal vascular obstructive skin disorder characterized by purpuric papules and plaques with capillary dilation. These lesions typically progress to crusted ulcers and ultimately result in fixed, white, atrophic stellate scars. T...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-05-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1537133/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850278575914090496 |
|---|---|
| author | Jing Qu Zhihong Hao Wang Junli Shengyou Yu Shengyou Yu |
| author_facet | Jing Qu Zhihong Hao Wang Junli Shengyou Yu Shengyou Yu |
| author_sort | Jing Qu |
| collection | DOAJ |
| description | BackgroundLivedoid vasculopathy (LV) is a rare, non-inflammatory, intradermal vascular obstructive skin disorder characterized by purpuric papules and plaques with capillary dilation. These lesions typically progress to crusted ulcers and ultimately result in fixed, white, atrophic stellate scars. The condition is marked by painful ulcers that heal slowly and have a tendency to recur.Case presentationWe report a case of a pediatric patient presenting with recurrent rashes and pain in both lower extremities. Physical examination revealed purpuric plaques with ulceration, scarring, and white atrophic healing features. Histopathological examination demonstrated intradermal thrombosis, vessel wall necrosis, and surrounding inflammatory cell infiltration with erythrocyte extravasation. Periodic acid-Schiff (PAS) staining was positive. The clinical and pathological findings were consistent with a diagnosis of LV. The patient was treated with oral rivaroxaban.ConclusionThis case highlights the critical importance of early recognition and intervention in the management of LV. Clinicians should consider LV in the differential diagnosis when encountering patients with painful purpuric rashes. Improvement in pain following treatment with anticoagulants, such as rivaroxaban, may indirectly support the diagnosis. A skin biopsy is essential for definitive diagnosis. |
| format | Article |
| id | doaj-art-97c97b71cd1b48df9f58cc2b69c5e4fe |
| institution | OA Journals |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-97c97b71cd1b48df9f58cc2b69c5e4fe2025-08-20T01:49:27ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-05-011310.3389/fped.2025.15371331537133A case report and literature review of livedoid vasculopathy in childrenJing Qu0Zhihong Hao1Wang Junli2Shengyou Yu3Shengyou Yu4Department of Pediatrics, Guangzhou First People’s Hospital, Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Pediatrics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, ChinaDepartment of Pediatrics, The Second Affiliated Hospital, South China University of Technology, Guangzhou, ChinaDepartment of Pediatrics, Guangzhou First People’s Hospital, Guangdong Medical University, Zhanjiang, Guangdong, ChinaDepartment of Pediatrics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, ChinaBackgroundLivedoid vasculopathy (LV) is a rare, non-inflammatory, intradermal vascular obstructive skin disorder characterized by purpuric papules and plaques with capillary dilation. These lesions typically progress to crusted ulcers and ultimately result in fixed, white, atrophic stellate scars. The condition is marked by painful ulcers that heal slowly and have a tendency to recur.Case presentationWe report a case of a pediatric patient presenting with recurrent rashes and pain in both lower extremities. Physical examination revealed purpuric plaques with ulceration, scarring, and white atrophic healing features. Histopathological examination demonstrated intradermal thrombosis, vessel wall necrosis, and surrounding inflammatory cell infiltration with erythrocyte extravasation. Periodic acid-Schiff (PAS) staining was positive. The clinical and pathological findings were consistent with a diagnosis of LV. The patient was treated with oral rivaroxaban.ConclusionThis case highlights the critical importance of early recognition and intervention in the management of LV. Clinicians should consider LV in the differential diagnosis when encountering patients with painful purpuric rashes. Improvement in pain following treatment with anticoagulants, such as rivaroxaban, may indirectly support the diagnosis. A skin biopsy is essential for definitive diagnosis.https://www.frontiersin.org/articles/10.3389/fped.2025.1537133/fulllivedoid vasculopathy (LV)white atrophyrivaroxabancapillarieschildren |
| spellingShingle | Jing Qu Zhihong Hao Wang Junli Shengyou Yu Shengyou Yu A case report and literature review of livedoid vasculopathy in children Frontiers in Pediatrics livedoid vasculopathy (LV) white atrophy rivaroxaban capillaries children |
| title | A case report and literature review of livedoid vasculopathy in children |
| title_full | A case report and literature review of livedoid vasculopathy in children |
| title_fullStr | A case report and literature review of livedoid vasculopathy in children |
| title_full_unstemmed | A case report and literature review of livedoid vasculopathy in children |
| title_short | A case report and literature review of livedoid vasculopathy in children |
| title_sort | case report and literature review of livedoid vasculopathy in children |
| topic | livedoid vasculopathy (LV) white atrophy rivaroxaban capillaries children |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1537133/full |
| work_keys_str_mv | AT jingqu acasereportandliteraturereviewoflivedoidvasculopathyinchildren AT zhihonghao acasereportandliteraturereviewoflivedoidvasculopathyinchildren AT wangjunli acasereportandliteraturereviewoflivedoidvasculopathyinchildren AT shengyouyu acasereportandliteraturereviewoflivedoidvasculopathyinchildren AT shengyouyu acasereportandliteraturereviewoflivedoidvasculopathyinchildren AT jingqu casereportandliteraturereviewoflivedoidvasculopathyinchildren AT zhihonghao casereportandliteraturereviewoflivedoidvasculopathyinchildren AT wangjunli casereportandliteraturereviewoflivedoidvasculopathyinchildren AT shengyouyu casereportandliteraturereviewoflivedoidvasculopathyinchildren AT shengyouyu casereportandliteraturereviewoflivedoidvasculopathyinchildren |