Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals
Background: Psoriasis is a chronic inflammatory skin condition affecting quality of life, with evidence suggesting a role for platelets in its pathogenesis. Mean Platelet Volume (MPV), a marker of platelet activation, may serve as a biomarker for systemic inflammation. This study aimed to compare M...
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| Format: | Article |
| Language: | English |
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ziauddin University
2025-01-01
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| Series: | Pakistan Journal of Medicine and Dentistry |
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| Online Access: | https://ojs.zu.edu.pk/pjmd/article/view/3235 |
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| author | Komal Shehzade Saulat Zahra Rabia Ishfaq Kayinat Samreen Maria Khalid Fahad Usman |
| author_facet | Komal Shehzade Saulat Zahra Rabia Ishfaq Kayinat Samreen Maria Khalid Fahad Usman |
| author_sort | Komal Shehzade |
| collection | DOAJ |
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Background: Psoriasis is a chronic inflammatory skin condition affecting quality of life, with evidence suggesting a role for platelets in its pathogenesis. Mean Platelet Volume (MPV), a marker of platelet activation, may serve as a biomarker for systemic inflammation. This study aimed to compare MPV levels between psoriasis patients and healthy controls to assess its clinical utility.
Methods: A comparative cross-sectional study was conducted at Imran Idrees Teaching Hospital, Sialkot, from October 25, 2023, to March 25, 2024, with 200 participants aged 20-60, selected via non-probability consecutive sampling. Exclusion criteria included recent surgery, obesity (BMI > 30), and cardiovascular disease. Participants were divided into psoriasis patients (n=31) and healthy controls (n=169). MPV was measured using a Swelab Lumi hematology analyzer, and data were analyzed using SPSS version 23.0, with t-tests for group comparisons (p<0.05).
Results: A total of 200 participants were included in the study, of which 15.5% were diagnosed with psoriasis. The mean MPV was significantly higher in the psoriasis group (8.86 ± 1.42 fL) compared to controls (7.23 ± 0.57 fL), with a p-value of 0.00002. This elevation in MPV suggests a potential association between platelet activation and psoriasis-related inflammation.
Conclusions: This study shows a significant difference in MPV levels between psoriasis patients and healthy controls, indicating a role for platelets in psoriasis pathogenesis. Elevated MPV may serve as a non-invasive biomarker for systemic inflammation. Further research is needed to validate its clinical utility in diagnosis and management.
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| format | Article |
| id | doaj-art-97c7a8c3569b462aa073a0dc23525893 |
| institution | Kabale University |
| issn | 2313-7371 2308-2593 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | ziauddin University |
| record_format | Article |
| series | Pakistan Journal of Medicine and Dentistry |
| spelling | doaj-art-97c7a8c3569b462aa073a0dc235258932025-01-19T20:18:32Zengziauddin UniversityPakistan Journal of Medicine and Dentistry2313-73712308-25932025-01-0114110.36283/ziun-pjmd14-1/011Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy IndividualsKomal Shehzade0Saulat Zahra1Rabia Ishfaq 2Kayinat Samreen3Maria Khalid4Fahad Usman5THQ Hospital Sambrial, Sialkot, Pakistan. Punjab Rangers Hospital, RMDC, Pakistan. Continental Medical CollegeDar-ul-Shifa HospitalTHQ Hospital Sambrial, Sialkot, Pakistan. Sialkot Medical College, Sialkot, Pakistan. Background: Psoriasis is a chronic inflammatory skin condition affecting quality of life, with evidence suggesting a role for platelets in its pathogenesis. Mean Platelet Volume (MPV), a marker of platelet activation, may serve as a biomarker for systemic inflammation. This study aimed to compare MPV levels between psoriasis patients and healthy controls to assess its clinical utility. Methods: A comparative cross-sectional study was conducted at Imran Idrees Teaching Hospital, Sialkot, from October 25, 2023, to March 25, 2024, with 200 participants aged 20-60, selected via non-probability consecutive sampling. Exclusion criteria included recent surgery, obesity (BMI > 30), and cardiovascular disease. Participants were divided into psoriasis patients (n=31) and healthy controls (n=169). MPV was measured using a Swelab Lumi hematology analyzer, and data were analyzed using SPSS version 23.0, with t-tests for group comparisons (p<0.05). Results: A total of 200 participants were included in the study, of which 15.5% were diagnosed with psoriasis. The mean MPV was significantly higher in the psoriasis group (8.86 ± 1.42 fL) compared to controls (7.23 ± 0.57 fL), with a p-value of 0.00002. This elevation in MPV suggests a potential association between platelet activation and psoriasis-related inflammation. Conclusions: This study shows a significant difference in MPV levels between psoriasis patients and healthy controls, indicating a role for platelets in psoriasis pathogenesis. Elevated MPV may serve as a non-invasive biomarker for systemic inflammation. Further research is needed to validate its clinical utility in diagnosis and management. https://ojs.zu.edu.pk/pjmd/article/view/3235PsoriasisPlatelet VolumeInflammation |
| spellingShingle | Komal Shehzade Saulat Zahra Rabia Ishfaq Kayinat Samreen Maria Khalid Fahad Usman Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals Pakistan Journal of Medicine and Dentistry Psoriasis Platelet Volume Inflammation |
| title | Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals |
| title_full | Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals |
| title_fullStr | Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals |
| title_full_unstemmed | Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals |
| title_short | Comparison of Mean Platelet Volume (MPV) in Patients with Psoriasis and Healthy Individuals |
| title_sort | comparison of mean platelet volume mpv in patients with psoriasis and healthy individuals |
| topic | Psoriasis Platelet Volume Inflammation |
| url | https://ojs.zu.edu.pk/pjmd/article/view/3235 |
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