Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report
Capecitabine is a widely used and effective oral chemotherapeutic agent for metastatic breast cancer and colorectal cancer; however, it is associated with several adverse effects. Of these effects, hand–foot syndrome (HFS) or palmar–plantar erythrodysesthesia, characterized by chronic inflammation,...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-09-01
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| Series: | Journal of Cancer Research and Practice |
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| Online Access: | https://journals.lww.com/jcrp/fulltext/2024/11030/squamous_cell_cancer_of_the_skin_in_a_patient_on.3.aspx |
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| author | Sidharth Mahajan Heather Moore Puneet Jolly Gretchen Kimmick |
| author_facet | Sidharth Mahajan Heather Moore Puneet Jolly Gretchen Kimmick |
| author_sort | Sidharth Mahajan |
| collection | DOAJ |
| description | Capecitabine is a widely used and effective oral chemotherapeutic agent for metastatic breast cancer and colorectal cancer; however, it is associated with several adverse effects. Of these effects, hand–foot syndrome (HFS) or palmar–plantar erythrodysesthesia, characterized by chronic inflammation, particularly of the hands and feet, is most notable. Chronic inflammation increases the risk of squamous cell cancers. We present a unique case of a patient with metastatic breast cancer whose disease was controlled with capecitabine for over a decade. She experienced chronic grade 1–2 HFS and subsequently developed squamous cell skin cancer on the palms and soles. To the best of our knowledge, squamous cell cancer associated with capecitabine exposure has not been previously reported. This case report aims to shed light on this association, thereby expanding the existing literature on the topic. |
| format | Article |
| id | doaj-art-97c25d8c70344d9e94d09f5edaa05a2b |
| institution | OA Journals |
| issn | 2311-3006 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Cancer Research and Practice |
| spelling | doaj-art-97c25d8c70344d9e94d09f5edaa05a2b2025-08-20T02:10:53ZengWolters Kluwer Medknow PublicationsJournal of Cancer Research and Practice2311-30062024-09-0111310710910.4103/ejcrp.eJCRP-D-24-00006Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case ReportSidharth MahajanHeather MoorePuneet JollyGretchen KimmickCapecitabine is a widely used and effective oral chemotherapeutic agent for metastatic breast cancer and colorectal cancer; however, it is associated with several adverse effects. Of these effects, hand–foot syndrome (HFS) or palmar–plantar erythrodysesthesia, characterized by chronic inflammation, particularly of the hands and feet, is most notable. Chronic inflammation increases the risk of squamous cell cancers. We present a unique case of a patient with metastatic breast cancer whose disease was controlled with capecitabine for over a decade. She experienced chronic grade 1–2 HFS and subsequently developed squamous cell skin cancer on the palms and soles. To the best of our knowledge, squamous cell cancer associated with capecitabine exposure has not been previously reported. This case report aims to shed light on this association, thereby expanding the existing literature on the topic.https://journals.lww.com/jcrp/fulltext/2024/11030/squamous_cell_cancer_of_the_skin_in_a_patient_on.3.aspxbreast cancercapecitabinehand–foot syndromepalmar–plantar erythrodysesthesiasquamous cell cancer |
| spellingShingle | Sidharth Mahajan Heather Moore Puneet Jolly Gretchen Kimmick Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report Journal of Cancer Research and Practice breast cancer capecitabine hand–foot syndrome palmar–plantar erythrodysesthesia squamous cell cancer |
| title | Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report |
| title_full | Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report |
| title_fullStr | Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report |
| title_full_unstemmed | Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report |
| title_short | Squamous Cell Cancer of the Skin in a Patient on Maintenance Capecitabine for Metastatic Breast Cancer: A Case Report |
| title_sort | squamous cell cancer of the skin in a patient on maintenance capecitabine for metastatic breast cancer a case report |
| topic | breast cancer capecitabine hand–foot syndrome palmar–plantar erythrodysesthesia squamous cell cancer |
| url | https://journals.lww.com/jcrp/fulltext/2024/11030/squamous_cell_cancer_of_the_skin_in_a_patient_on.3.aspx |
| work_keys_str_mv | AT sidharthmahajan squamouscellcanceroftheskininapatientonmaintenancecapecitabineformetastaticbreastcanceracasereport AT heathermoore squamouscellcanceroftheskininapatientonmaintenancecapecitabineformetastaticbreastcanceracasereport AT puneetjolly squamouscellcanceroftheskininapatientonmaintenancecapecitabineformetastaticbreastcanceracasereport AT gretchenkimmick squamouscellcanceroftheskininapatientonmaintenancecapecitabineformetastaticbreastcanceracasereport |