Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma
Langerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves the stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. We report the first case of gastric LCH in a 9-year-old boy who was misdiagnosed with ga...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1443553/full |
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| author | Zhi Wan Zhi Wan Xue Tang Xue Tang Ju Gao Ju Gao Jing-jing Sun Jing-jing Sun |
| author_facet | Zhi Wan Zhi Wan Xue Tang Xue Tang Ju Gao Ju Gao Jing-jing Sun Jing-jing Sun |
| author_sort | Zhi Wan |
| collection | DOAJ |
| description | Langerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves the stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. We report the first case of gastric LCH in a 9-year-old boy who was misdiagnosed with gastric lymphoma. The patient presented to our outpatient department with recurrent abdominal pain that had lasted 1 month. Due to the absence of typical clinical features associated with lymphoma in the boy, the initial diagnosis of lymphoma based on the first gastric pathological biopsy was questioned. The second pathological examination revealed that the tumor cells expressed CD1a, S-100, and Langerin with BRAF (c.1457_1471del) deletion mutations. The patient’s condition rapidly improved after chemotherapy with prednisone and vincristine. This case report focuses on the possibility of gastric LCH in school-aged children and the differential diagnosis of gastric tumors in children. |
| format | Article |
| id | doaj-art-97bd0624e818428da829f25c3b6d186e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-97bd0624e818428da829f25c3b6d186e2025-01-22T07:14:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14435531443553Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphomaZhi Wan0Zhi Wan1Xue Tang2Xue Tang3Ju Gao4Ju Gao5Jing-jing Sun6Jing-jing Sun7Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, ChinaKey Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, ChinaLangerhans cell histiocytosis (LCH) is a myeloid neoplasm associated with the infiltration of most organs but rarely involves the stomach. Stomach tumors in children are very rare and can be easily misdiagnosed. We report the first case of gastric LCH in a 9-year-old boy who was misdiagnosed with gastric lymphoma. The patient presented to our outpatient department with recurrent abdominal pain that had lasted 1 month. Due to the absence of typical clinical features associated with lymphoma in the boy, the initial diagnosis of lymphoma based on the first gastric pathological biopsy was questioned. The second pathological examination revealed that the tumor cells expressed CD1a, S-100, and Langerin with BRAF (c.1457_1471del) deletion mutations. The patient’s condition rapidly improved after chemotherapy with prednisone and vincristine. This case report focuses on the possibility of gastric LCH in school-aged children and the differential diagnosis of gastric tumors in children.https://www.frontiersin.org/articles/10.3389/fonc.2024.1443553/fulllangerhans cell histiocytosisstomachBRAFchildlymphoma |
| spellingShingle | Zhi Wan Zhi Wan Xue Tang Xue Tang Ju Gao Ju Gao Jing-jing Sun Jing-jing Sun Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma Frontiers in Oncology langerhans cell histiocytosis stomach BRAF child lymphoma |
| title | Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma |
| title_full | Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma |
| title_fullStr | Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma |
| title_full_unstemmed | Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma |
| title_short | Case report: Gastric langerhans cell histiocytosis with BRAF deletion mutation in a child that was misdiagnosed as lymphoma |
| title_sort | case report gastric langerhans cell histiocytosis with braf deletion mutation in a child that was misdiagnosed as lymphoma |
| topic | langerhans cell histiocytosis stomach BRAF child lymphoma |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1443553/full |
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