Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes
Objective. To examine the different impacts of MS components on insulin resistance in type 2 diabetes. Methods. A number of subjects (144) who met the criteria of (1) age between 30 and 75 years, (2) had type 2 diabetes for more than one year, and (3) taking gliclazide and metformin for more than 6...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/740419 |
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| _version_ | 1849403859598835712 |
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| author | Chung-Hua Hsu |
| author_facet | Chung-Hua Hsu |
| author_sort | Chung-Hua Hsu |
| collection | DOAJ |
| description | Objective. To examine the different impacts of MS components on insulin resistance in type 2 diabetes. Methods. A number of subjects (144) who met the criteria of (1) age between 30 and 75 years, (2) had type 2 diabetes for more than one year, and (3) taking gliclazide and metformin for more than 6 months were enrolled. All subjects were assigned to one of the four HOMA index categories. The HOMA index quartile 4 denotes the highest insulin resistance. The main outcome evaluated is the odds ratios (ORs) of different MS components on HOMA index quartile 4. The characteristics in HOMA index quartiles and groups of nonmetabolic syndrome (NMS; number of components < 2), metabolic syndrome A (MSA; number of components = 2), and metabolic syndrome B (MSB; number of components > 2) were also evaluated. Results. The results showed that both MSA and MSB groups had higher ORs (5.9 and 13.8 times, resp.) than the NMS group; and that subjects with large waist circumference (LWC) and high triglyceride (HTG) level have higher ORs (6.1 and 2.6 times, resp.) in developing higher insulin resistance than normal control subjects. Conclusion. Type 2 diabetic patients with greater number of MS components have higher ORs in developing increased insulin resistance. |
| format | Article |
| id | doaj-art-97bceadbca3e49258a84d0a60e2933b0 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-97bceadbca3e49258a84d0a60e2933b02025-08-20T03:37:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452013-01-01201310.1155/2013/740419740419Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 DiabetesChung-Hua Hsu0Institute of Traditional Medicine, National Yang-Ming University, Taipei 112, TaiwanObjective. To examine the different impacts of MS components on insulin resistance in type 2 diabetes. Methods. A number of subjects (144) who met the criteria of (1) age between 30 and 75 years, (2) had type 2 diabetes for more than one year, and (3) taking gliclazide and metformin for more than 6 months were enrolled. All subjects were assigned to one of the four HOMA index categories. The HOMA index quartile 4 denotes the highest insulin resistance. The main outcome evaluated is the odds ratios (ORs) of different MS components on HOMA index quartile 4. The characteristics in HOMA index quartiles and groups of nonmetabolic syndrome (NMS; number of components < 2), metabolic syndrome A (MSA; number of components = 2), and metabolic syndrome B (MSB; number of components > 2) were also evaluated. Results. The results showed that both MSA and MSB groups had higher ORs (5.9 and 13.8 times, resp.) than the NMS group; and that subjects with large waist circumference (LWC) and high triglyceride (HTG) level have higher ORs (6.1 and 2.6 times, resp.) in developing higher insulin resistance than normal control subjects. Conclusion. Type 2 diabetic patients with greater number of MS components have higher ORs in developing increased insulin resistance.http://dx.doi.org/10.1155/2013/740419 |
| spellingShingle | Chung-Hua Hsu Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes International Journal of Endocrinology |
| title | Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes |
| title_full | Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes |
| title_fullStr | Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes |
| title_full_unstemmed | Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes |
| title_short | Different Impacts of Metabolic Syndrome Components on Insulin Resistance in Type 2 Diabetes |
| title_sort | different impacts of metabolic syndrome components on insulin resistance in type 2 diabetes |
| url | http://dx.doi.org/10.1155/2013/740419 |
| work_keys_str_mv | AT chunghuahsu differentimpactsofmetabolicsyndromecomponentsoninsulinresistanceintype2diabetes |